脑白质高信号患者的执行功能与大脑皮层厚度和体积的相关性
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1.首都医科大学附属北京天坛医院神经病学中心;2.首都医科大学附属北京天坛医院康复医学部;3.首都医科大学附属北京天坛医院影像中心;4.海南医学院第一附属医院神经内科;5.首都医科大学附属北京康复医院

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国家重点研发计划(2020YFC2004105,2020YFC2004102),首发(2022-1-2251),国家自然科学基金(81972144,81972148)


Cortical thickness and volume changes are associated with executive function in patients with white matter hyperintensities
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    摘要:

    目的:探讨脑白质高信号(WMH)患者皮层厚度和体积的特点及其与执行功能的关系。 方法:研究共招募了80名WMH患者(病例组)和42名健康受试者(对照组)。根据北京版蒙特利尔认知评估,将病例组分为两个亚组,即WMH认知正常组(WMH-CN)和WMH认知障碍组(WMH-CI)。记录研究对象的人口统计学信息和脑血管病危险因素。所有研究对象接受3D头部磁共振成像,执行功能评估采用Stroop 色词干扰测验、连线测验、数字符号测验、言语流畅性测验。我们比较了病例组和对照组间执行功能和大脑皮层厚度及体积的差异。Pearson 相关分析了大脑皮层厚度和体积与执行功能之间的相关性。 结果:两组人口学特征无显着差异(P> 0.05)。病例组和对照组之间MoCA评分(P <0.01)和执行功能(P <0.01)存在显着差异。WMH-CN组、WMH-CI组的额叶、颞叶、岛叶皮层厚度和体积小于对照组(P< 0.05)。WMH-CN组执行功能与额叶、颞叶的皮层厚度正相关(P< 0.05),与额叶、颞叶、岛叶的皮层体积正相关(P< 0.05)。WMH-CI组执行功能与额叶、颞叶、岛叶的皮层厚度和体积正相关(P< 0.05)。 结论:脑白质高信号患者存在额叶、颞叶、岛叶皮层萎缩。这些脑区的皮层萎缩与执行功能减退有关。

    Abstract:

    Objective: To investigate the characteristics of cortical thickness and volume in patients with cerebral white matter hyperintensities(WMH) and their relationship with executive function. Methods: A total of 80 patients with white matter hyperintensities and 42 healthy controls were recruited for the study. The patients were further divided into two subgroups, namely WMH with cognitive normal (WMH-CN) and WMH with cognitive impairment (WMH-CI) according to the Beijing version of the Montreal Cognitive Assessment (MoCA).Demographic information and risk factors for cerebrovascular disease were recorded. All subjects underwent 3D brain magnetic resonance imaging, and executive function was assessed using the Stroop Color and Word Test, Trail-making Test, Digit Symbol Test, and Verbal Fluency Test. Pearson correlation analysis was performed to determine the association between cortical thickness and volume with executive function. Results: In the comparison between WHM group and healthy controls, there were no significant differences in demographic characteristics and vascular risk factors (P > 0.05),while there were significant differences in MoCA scores (P < 0.01) and executive function (P < 0.01). The cortical thickness and volume of frontal, temporal, and insular lobes in the WMH-CN and WMH-CI groups were less than those of healthy controls (P < 0.05). Executive function in the WMH-CN group was positively correlated with cortical thickness in frontal and temporal lobes and with cortical volume in the frontal, temporal, and insular lobes (P< 0.05). Executive function in the WMH-CI group was positively correlated with cortical thickness and volume in the frontal, temporal, and insular lobes (P< 0.05). Conclusion: Patients with white matter hyperintensities exhibit cortical atrophy in frontal, temporal, and insula lobes. Cortical atrophy in these brain regions is associated with executive dysfunction.

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  • 收稿日期:2023-02-07
  • 最后修改日期:2023-04-17
  • 录用日期:2023-05-23
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