不同年龄分层下内脏脂肪指数与认知能力障碍的相关性研究
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1.西安交通大学第一附属医院 肾内科西安;2.西安交通大学医院 内科西安;3.西安交通大学医院 内科 西安;4.西安交通大学第一附属医院 神经内科西安

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陕西省基金(2023-JC-YB-736),国家自然科学基金项目(面上项目,重点项目,重大项目)


Analysis of relationship between visceral fat index and cognitive impairmentby age stratification
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1.Department of Nephrology,The First Affiliated Hospital of Xi'2.'3.an Jiaotong University,Xi'4.an;5.Department of Neurology,The First Affiliated Hospital of Xi&6.amp;7.#39;8.&9.an Jiaotong University,Xi&

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    摘要:

    目的:探讨中国内脏脂肪指数(Chinese visceral adiposity index,CVAI)与认知能力障碍(Cognitive Impairment ,CI)的相关性,并进一步分析不同年龄分层下两者的相关性,为准确评估两者关系,提供新的可干预的认知功能影响因素提供依据。方法:选取CHARLS数据库2011和2015年的数据,包括研究对象的性别、年龄、教育程度、饮酒、吸烟史以及体重指数和生化指标。应用Logistic回归分VAI与CI的相关性,并根据不同年龄进行分层分析。 结果:1.在12102名研究对象中,认知能力障碍者为1295(10.7%);2. 在65岁及以上人群中,CVAI与CI具有相关性(p<0.05),而在65岁以下人群中CVAI与CI无明显相关性;3.利用截断值(161.94)分为高CVAI组(CVAI≥161.94)和低CVAI组(CVAI<161.94);4.年龄与CI正相关(OR=2.24,95%CI:1.66~3.03),教育程度与CI负相关(OR=0.71,95%CI:0.53~0.94),在65岁及以上人群,高CVAI与CI正相关(OR=1.42,95%CI:1.04~1.93),差异有统计学意义(P均<0.05);结论:1. 内脏脂肪指数、年龄、教育程度均与认知能力障碍相关; 2.在65岁及以上人群,高内脏脂肪指数是认知能力障碍的危险因素。

    Abstract:

    Objective: To explore the correlation between Chinese Visceral Adiposity Index (CVAI) and Cognitive Impairment (CI), and further analyze the correlation between CVAI and CI under different age levels. To provide evidence for accurately evaluating the relationship between CVAI and CI,and seeking for clinically relevant, non-invasive factors associated with CI. Methods: The CHARLS database was used in this study. And the baseline data were collected of 2011 and 2015, including gender, age, education level, alcohol consumption, smoking history, body mass index and biochemical indicators. Spearman correlation analysis was used analyze the association of CVAI and CI. Logistic regression analysis was used for multivariate analysis. Results: 1. A total of 12102 subjects were included in this study, 1295 (10.7%) were cognitive impairment. 2. There was a correlation between CVAI and CI in people aged 65 and above (p<0.05), but no significant correlation between CVAI and CI in people aged below 65(P>0.05); 3. The best cut-off value of CVAI for CI was 161.94, and the cut-off value was divided into high CVAI group (CVAI≥161.94) and low CVAI group (CVAI<161.94). 4. After adjusting for confounding factors, age was positively correlated with CI (OR=2.24,95%CI:1.66~3.03), education level was negatively correlated with CI (OR=0.71,95%CI:0.53~0.94), and high CVAI was negatively correlated with CI in people aged 65 and above(OR=1.42,95%CI:1.04~1.93), the difference was statistically significant (P<0.05); Conclusions: 1. Visceral fat index, age and education were correlated with cognitive impairment; 2. High visceral fat index is a risk factor for cognitive impairment in people 65 years and older.

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  • 收稿日期:2023-02-13
  • 最后修改日期:2023-03-15
  • 录用日期:2023-08-29
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