电压门控钠离子通道在难治性癫痫中的作用机制研究进展
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南京医科大学药学院

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国家自然科学基金(82001376)


Research progress on the role and mechanisms of voltage-gated sodium channels in treatment-resistant epilepsy
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School of Pharmacy,Nanjing Medical University,Nanjing

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The National Natural Science Foundation of China

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    摘要:

    癫痫是一种常见神经系统慢性疾病。国际抗癫痫联盟(ILAE)将癫痫发作定义为:由于大脑中异常过度或同步化的神经元活动导致的体征或症状的短暂发生。大约70%患者通过适当药物治疗有效控制癫痫发作,但仍有约1/3患者对现有抗癫痫药物(AEDs)治疗没有反应。电压门控钠离子通道(VGSCs)的α亚基由一个高度保守的基因家族进行编码,其中SCN1A、SCN2A和SCN8A基因突变是中枢神经系统疾病的重要病因。已有研究表明,VGSCs在难治性癫痫(TRE)病理进程中发挥重要作用。本文对TRE概念、发病和耐药机制进行全面分析,并综述了VGSCs介导TRE机制研究的进展。

    Abstract:

    Epilepsy is a common chronic neurological disease. The International League Against Epilepsy (ILAE) defines seizures as: the transient occurrence of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain. About 70% of patients achieve seizure-free with appropriate medical treatment, but nearly one-third of patients still do not respond to current antiepileptic drugs (AEDs). The alpha subunits of voltage-gated sodium channels (VGSCs) are encoded by a highly conserved gene family, of which mutations in SCN1A, SCN2A, and SCN8A genes are important causes of central nervous system diseases. Previous studies have shown that voltage-gated sodium channels play an important role in the pathological process of treatment-resistant epilepsy (TRE). In this paper, the concept, pathogenesis and drug resistance mechanism of treatment-resistant epilepsy were introduced in detail, meanwhile the role and mechanisms of voltage-gated sodium channels in treatment-resistant epilepsy were reviewed.

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  • 收稿日期:2023-02-15
  • 最后修改日期:2023-03-17
  • 录用日期:2023-05-23
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