脂肪间充质干细胞在纤维化疾病治疗中的作用
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南京中医药大学附属医院肾内科

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国家自然科学基金项目(面上项目,重点项目,重大项目)


The role of adipose-derived mesenchymal stem cells in the treatment of fibrotic diseases
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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    纤维化疾病由于其广泛性和复杂性带来了重大临床挑战,探究纤维化的发生机制并寻求更有效的治疗方法势在必行。脂肪来源的间充质干细胞(adipose-derived stem cells,ADSCs)是适用于再生医学的理想干细胞,可作为许多疾病的替代治疗方案。近年来研究表明,ADSCs有显著的抗纤维化潜力。本文就ADSCs抗组织纤维化过程中涉及的上皮-间充质转变、成纤维细胞活化、抗炎及免疫调节等潜在干预靶点进行综述,旨在为防治纤维化提供新思路。

    Abstract:

    Fibrotic diseases have brought great clinical challenges due to their extensiveness and complexity. It is imperative to explore the mechanism of fibrosis and seek more effective treatments.Adipose derived stem cells (ADSCs) are ideal stem cells for regenerative medicine and can be used as an alternative treatment for many diseases.Recent studies have shown that ADSCs have significant anti-fibrosis potential. This article reviews the potential intervention targets involved in the anti-fibrosis process of ADSCs, such as epithelial-mesenchymal transition, fibroblast activation, anti-inflammatory and immune regulation, in order to provide new ideas for the prevention and treatment of fibrosis.

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  • 收稿日期:2023-02-23
  • 最后修改日期:2023-07-19
  • 录用日期:2024-02-27
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