Androgenic alopecia, also termed as seborrheic alopecia, is the most common type of clinical alopecia. The hair follicles miniaturization acts as a main clinical manifestation. Currently it has been considered for many reasons to induce hair follicle miniaturization. On the one hand, it promotes dermal papilla cells of scalp hair follicle of patients to secrete hair follicle inhibitory factor, and dermal papilla cells have apoptosis and autophagy disorder; on the other hand, they destroy microvasculature surrounding the dermal papilla. In addition, they also cause depletion of hair follicle stem cells, and eventually causing the gradual transition from the initial terminal hair to thin pili. This review discusses the update mechanism of hair follicle miniaturization resulting from distinct type of hair negative factor and holds substantial promise for the future treatment.