戊型肝炎重症化与慢性化免疫学机制研究进展
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南京医科大学护理学院,基础与社区护理学系

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江苏省卫生健康发展研究中心开放课题(编号:JSHD2022046)


Research advances in the immune pathogenesis of HEV related liver failure and chronic hepatitis E
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Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University Nanjing

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    摘要:

    戊型肝炎是由戊型肝炎病毒感染引起的一种急、慢性传染性疾病,是全球范围内一项重要的公共卫生问题。尽管戊型肝炎通常被认为是一种无症状、自限性疾病,但其临床表现呈多样性变化,部分患者可出现重症化或慢性化进展,造成不良预后,危害较为严重。免疫反应是决定戊型肝炎患者临床表现和结局的关键因素,正常的免疫反应有助于病毒清除和疾病康复,而过度或紊乱的免疫反应则可导致该病进展,参与其重症化和慢性化进程。本文通过文献回顾,从天然免疫反应和适应性免疫反应两个方面对戊型肝炎重症化及慢性化的免疫学机制进行综述,以期为该类患者的早期预测、临床防治和疾病管理提供理论依据和新思路。

    Abstract:

    Hepatitis E is an acute and chronic infectious disease caused by hepatitis E virus infection, which is a significant public health concern worldwide. Although hepatitis E is generally considered an asymptomatic, self-limiting disease, its clinical manifestations vary, some individuals may develop severe or chronic progression, resulting in poor prognosis and serious harm. Immune response is a key factor determining the clinical manifestation and outcome of hepatitis E. Normal immune response helps virus clearance and recovery of this disease, while excessive or disordered immune response can lead to disease progression and participate in the severe and chronic progression of the disease. Through literature review, this article summarizes the immunological mechanisms of HEV related liver failure and chronic hepatitis E, including innate immune response and adaptive immune response, in order to provide theoretical basis and new ideas for early prediction and prevention, treatment and management of this disease.

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  • 收稿日期:2023-04-07
  • 最后修改日期:2023-04-26
  • 录用日期:2023-10-20
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