血清IL-9水平对急性脑梗死患者早期神经功能恶化的预测价值研究
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1.江苏大学附属医院;2.江苏大学附属宜兴医院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Study on the predictive value of serum IL-9 level in the early deterioration of neurological function after acute cerebral infarction.
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    摘要:

    目的:探讨血清白介素(Interleukin, IL)9水平在急性脑梗死早期神经功能恶化(Early neurological deterioration, END)患者血清中的表达变化并评估其对END的预测价值。 方法:收集106例脑梗死患者,根据是否发生END,将脑梗死患者分为END组42例,非END组64例,收集脑梗死患者的一般资料,并记录入院时美国国立卫生院神经功能缺损(National Institute of Health stroke scale, NIHSS)评分,检测血清生化指标、基线期血清IL-9、C反应蛋白(C-reactive protein, CRP)和IL-6水平。相关性的评估采用Pearson或Spearman相关性分析,采用Logistic回归分析脑梗死患者发生END的影响因素,并绘制ROC曲线评估血清IL-9水平在脑梗死发生END中的预测价值。结果: END组糖尿病比例、颈动脉狭窄>50%比例、低密度脂蛋白、糖化血红蛋白和入院时NIHSS评分均高于非END组(P<0.05)。END组血清IL-9水平明显高于非END组(P<0.01)。脑梗死患者血清IL-9水平与入院时NIHSS评分呈正相关(r=0.535,P<0.01)。Logistic回归显示血清IL-9水平、颈动脉狭窄>50%和入院时NIHSS评分为END发生的危险因素(P<0.01)。血清IL-9水平预测END发生的ROC曲线下面积为0.815。血清IL-9水平与血清CRP水平(r=0.648,P<0.01)和IL-6水平(r=0.765,P<0.01)均呈正相关。结论:血清IL-9水平在脑梗死END患者中明显升高,对END的发生具有良好的预测作用。

    Abstract:

    Objective: To explore the expression changes of serum interleukin(IL)9 level in patients with acute cerebral infarction and evaluate its value. Methods: 106 patients with cerebral infarction were collected. According to whether or not early neurological deterioration (END) occurred, the patients with cerebral infarction were divided into END group (42 cases) and non-END group (64 cases). The general data of patients with cerebral infarction were collected, and the National Institute of Health stroke scale (NIHSS) score was recorded, and serum biochemical indices, serum IL-9, C-reactive protein (CRP) and IL-6 levels at baseline were detected. Pearson or Spearman correlation analysis was used to evaluate the correlation. Logistic regression was used to analyze the factors affecting the occurrence of END in patients with cerebral infarction, and ROC curve was drawn to evaluate the predictive value of serum IL-9 level in the occurrence of END of cerebral infarction. Results: The proportion of diabetes mellitus, carotid artery stenosis>50%, low density lipoprotein, glycosylated hemoglobin and NIHSS score at admission in END group were all higher than those in non-END group (P<0.05). The level of serum IL-9 in the END group was significantly higher than that in the non-END group (P<0.01). The level of serum IL-9 in patients with cerebral infarction was positively correlated with NIHSS score at admission (r=0.535, P<0.01). Logistic regression showed that serum IL-9 level, carotid artery stenosis > 50% and NIHSS score at admission were risk factors for END (P<0.01). The area under ROC curve of serum IL-9 level predicting END occurrence was 0.815. Serum IL-9 level was positively correlated with serum CRP level (r=0.648, P<0.01) and serum IL-6 level (r=0.765, P<0.01), respectively. Conclusion: Serum IL-9 level is significantly increased in patients with cerebral infarction END, which has a good predictive effect on the occurrence of END.

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  • 收稿日期:2023-04-11
  • 最后修改日期:2023-07-17
  • 录用日期:2023-10-18
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