Parkinson's disease (PD) is a neurodegenerative disease with complex pathogenesis and variable clinical manifestations. However, there still stand many challenges in the pathogenesis and early diagnosis. Recently, positron emission tomography-magnetic resonance (PET/MR) has emerged as a truly multi-modal imaging tool, which could precisely extract and combine physiological and metabolic information in different time and space, and thereby enrich imaging basis for the translation of PD from molecular level to diagnosis and treatment.