Osteoporosis (OP) is a common disease in the elderly, characterized by decreased bone strength, decreased bone density, and increased risk of fractures. Ferroptosis is a novel iron-dependent programmed cell death (PCD) process that is critical in regulating the development of osteoporosis , but its underlying mechanism is complex. This article discusses the molecular mechanism of ferroptosis in osteoporosis and related research progress, in order to provide new reference for future research on ferroptosis and osteoporosis.