间质性肺疾病合并肺癌的机制及治疗进展
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南京医科大学第一附属医院呼吸与危重症医学科

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国家自然科学基金项目(面上项目,重点项目,重大项目);江苏省科教能力提升工程


Pathogenic Mechanisms and Therapeutic Advancements in Interstitial Lung Disease with Lung Cancer
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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan);Jiangsu Province Capability Improvement Project through Science,Technology and Education

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    摘要:

    间质性肺病(interstitial lung disease, ILD)患者肺癌发生率高,合并ILD的肺癌患者生存期短、死亡率高、治疗难度大。ILD及肺癌有共同的危险因素及相似的发病机制。肺癌治疗常可引起ILD及ILD急性加重。一些靶向两者相似发病机制的药物在肺癌合并ILD的治疗中展现出良好疗效。本文就ILD合并肺癌的发病机制、治疗风险及治疗进展进行综述,以期提高临床医师对该病的诊治水平。

    Abstract:

    Interstitial lung disease (ILD) is associated with a higher incidence of lung cancer, and lung cancer patients with concomitant ILD have a poor prognosis with high mortality and treatment challenges. ILD and lung cancer share similar risk factors and pathogenesis. Treatment of lung cancer may trigger acute exacerbations of ILD or cause ILD as an adverse event. Various agents targeting common pathogenic mechanisms of lung cancer and ILD have been demonstrated to be promising therapeutic drug. This review provides a comprehensive analysis of the epidemiology, risks, and therapeutic strategies of ILD with lung cancer, aiming to enhance awareness and recognition of this disease in clinical practice from an academic perspective.

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  • 收稿日期:2023-05-25
  • 最后修改日期:2023-07-02
  • 录用日期:2024-02-27
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