循环肿瘤DNA检测在胃肠间质瘤诊疗中的价值
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昆明医科大学第二附属医院

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院士专家工作站(202205AF150011);国家自然科学基金(81960508)


The value of circulating tumor DNA detection in the diagnosis and treatment of gastrointestinal stromal tumors
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Academician Expert Workstation (202205AF150011); National Natural Science Foundation of China (81960508)

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    摘要:

    胃肠间质瘤(gastrointestinal stromal tumor,GIST)起源于胃肠道间叶组织,多数继发于KIT/PDGFRA基因突变,这一发现对于胃肠间质瘤的基础研究和临床诊疗进程具有里程碑式的意义。基因检测被广泛运用于明确胃肠间质瘤的病理诊断、判断预后及指导靶向药物治疗等诸多领域。近年来众多研究表明包括循环肿瘤DNA (circulating tumor DNA, ct DNA)检测在内的液体活检技术对于胃肠间质瘤的诊疗展现出极其重要的临床价值和广阔的应用前景,本文就循环肿瘤DNA检测运用于胃肠间质瘤诊疗中的价值做一综述。

    Abstract:

    Gastrointestinal stromal tumors (GIST) originate from gastrointestinal mesenchymal tissue, and most of them are secondary to KIT/PDGFRA gene mutations. This discovery has a landmark significance for the basic research and clinical diagnosis and treatment of GIST. Genetic testing is widely used in many fields, such as identifying pathological diagnosis of gastrointestinal stromal tumor (GIST), judging prognosis and guiding targeted drug therapy. In recent years, numerous studies have shown that liquid biopsy techniques, including circulating tumor DNA (ct DNA) detection, have shown extremely important clinical value and broad application prospect for the diagnosis and treatment of gastrointestinal stromal tumor (GIST). This article reviews the value of circulating tumor DNA (ctDNA) detection in the diagnosis and treatment of gastrointestinal stromal tumors (GIST).

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  • 收稿日期:2023-05-27
  • 最后修改日期:2023-07-01
  • 录用日期:2023-10-25
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