简述增强子及其调控异常与恶性肿瘤的功能联系
DOI:
作者:
作者单位:

南京医科大学

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


Research advances of relationship between abnormal regulation of enhancer and malignant tumor
Author:
Affiliation:

Nanjing Medical University

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    增强子是真核生物基因组中一类特殊的转录调控元件,真核生物的基因组中分布着大量增强子元件。增强子可通过形成染色质环结构与靶基因的启动子相互作用,与启动子共同调控靶基因转录和细胞的命运。大量研究表明,遗传变异,表观修饰改变及转录因子异常均会直接或间接导致增强子功能失调或基因组增强子重塑,并与恶性肿瘤的发生和恶性进展密切相关。近年来高通量测序技术和数据库的快速发展有力推进了增强子研究的深度和广度。本文对增强子的结构特征、调控模式,在肿瘤发生和发展过程中调控异常的形成机制、增强子鉴定的主要技术手段及常用数据库进行了简要的概括和介绍。

    Abstract:

    Enhancer is a special class of transcriptional regulatory elements in eukaryotic genomes. There are a large number of enhancer elements in eukaryotic genomes. Enhancers can interact with the promoters of target genes through the formation of chromatin loop, and regulate the transcription of target genes and the fate of cells together with the promoters. A large number of studies have shown that genetic variation, epigenetic modification and abnormal transcription factors can directly or indirectly lead to enhancer dysfunction or genome enhancer remodeling, and are closely related to the occurrence and progression of malignant tumor. In recent years, the rapid development of high-throughput sequencing technology and database has strongly promoted the depth and breadth of enhancer research. In this paper, the structural characteristics of enhancers, the regulation mode, the formation mechanism of abnormal regulation in the process of tumor occurrence and development, the main technical means of enhancer identification and common databases are briefly summarized and introduced.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-05-31
  • 最后修改日期:2023-06-22
  • 录用日期:2023-10-20
  • 在线发布日期:
  • 出版日期: