伴FLT3突变的急性髓系白血病患者淋巴细胞亚群和细胞因子的表达水平及意义
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1.南京医科大学附属江宁医院 血液内科;2.南京医科大学附属江宁医院 输血科;3.南京医科大学第一附属医院 血液内科

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南京市医学科技发展项目,


Expression and significance of lymphocyte subgroups andcytokines in acute myeloid leukemia patients with FLT3 mutations
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Department of Hematology,The Affiliated Jiangning Hospital of Nanjing Medical University

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    摘要:

    目的:探讨伴FMS样酪氨酸激酶3受体(FMS like tyrosine kinase 3 receptor,FLT3)突变的初诊急性髓系白血病(acute myeloid leukemia,AML)患者外周血淋巴细胞亚群、细胞因子表达水平及其与血细胞计数、突变类型之间的相关性。方法:168例伴FLT3突变的AML患者纳入研究,进一步对FLT3突变类型进行分类,收集患者的治疗前外周血淋巴细胞亚群、细胞因子数据及血细胞计数,分析其之间的相关性。结果:伴FLT3突变的AML患者,与健康对照组相比,治疗前外周血CD4、IL-6、IL-10表达水平升高,CD8、CD16+CD56、IL-2、TNF、IFN-γ表达水平下降。按白细胞计数分组,CD3、CD4、CD8、CD19、IL-4、IL-10在组间分布具有差异性(P=0.0385、P=0.0235、P=0.0338、P=0.0084、P=0.0478、P=0.0241);按血小板计数分组,CD19、CD16+CD56在组间分布具有差异性(P=0.0298、P=0.0453)。按FLT3类型进行分组,分为FLT3-ITD+、FLT3-TKD+、FLT3-(ITD++TKD+)和FLT3-(ITD-+TKD-),CD3、CD8、CD19、IL-10、TNF在四组间分布具有差异性(P=0.0460、P=0.0484、P=0.0412、P=0.0415、P=0.0126)。结论:伴FLT3突变的AML患者,其淋巴细胞亚群及细胞因子表达水平与正常对照组相比,具有差异性;血细胞计数及FLT3突变类型对其表达水平,可能具有一定的影响。

    Abstract:

    Objective: To investigate the correlation between lymphocyte subsets and cytokine expression levels and blood cell count and mutation types in peripheral blood of newly diagnosed AML patients with FLT3 mutations. Methods: A total of 168 AML patients with FLT3 mutations were included in the study. FLT3 mutation types were further classified, and lymphocyte subsets, cytokines and blood cell count in peripheral blood of patients before treatment were collected to analyze their correlation. Results: Compared with the healthy control group, the expression levels of CD4, IL-6, and IL-10 in peripheral blood of patients with FLT3 mutations were increased before treatment, while the expression levels of CD8, CD16+CD56, IL-2, TNF, and IFN-γ were decreased. According to leukocyte count, the distributions of CD3, CD4, CD8, CD19, IL-4 and IL-10 were different among the groups (P=0.0385, P=0.0235, P=0.0338, P=0.0084, P=0.0478, P=0.0241). According to platelet count, the distributions of CD19, CD16+CD56 were different among groups (P=0.0298, P=0.0453). It can be divided into FLT3-ITD+、FLT3-TKD+、FLT3-(ITD++TKD+)and FLT3-(ITD-+TKD-). The distributions of CD3, CD8, CD19, IL-10 and TNF were different among the four groups (P=0.0460, P=0.0484, P=0.0412, P=0.0415, P=0.0126). Conclusion: The expression levels of lymphocyte subsets and cytokines in AML patients with FLT3 mutations were different compared to control group. Blood cell count and FLT3 mutation types may influence their expression level.

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  • 收稿日期:2023-06-04
  • 最后修改日期:2023-11-30
  • 录用日期:2024-02-27
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