晨尿联合盆腔超声、多普勒子宫动脉成像在女童中枢性性早熟诊断中的应用
DOI:
作者:
作者单位:

1.阜宁县人民医院;2.南京医科大学附属淮安第一医院儿科

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省妇幼保健项目(FYX202213)


Application of morning urine combined with pelvic ultrasound and Doppler uterine artery imaging in the diagnosis of central precocious puberty in girls
Author:
Affiliation:

Fund Project:

Jiangsu Maternal and Child Health Care Project (FYX202213)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨晨尿联合盆腔超声、多普勒子宫动脉成像在初诊女童中枢性性早熟(CPP)中的应用价值。方法:选取2022年4月至2023年5月就诊于徐州医科大学淮安临床学院儿科的96例性早熟女童为研究对象,收集患儿年龄、体重、身高等资料,检查血清基础黄体生成素(LH)、雌二醇水平,收集晨尿测定LH和卵泡刺激素(FSH)水平,检测骨龄,同时进行盆腔多普勒彩超检查评估子宫动脉搏动指数(PI)、子宫长径、横径、前后径,计算子宫容积、卵巢容积等。行促性腺激素释放激素(GnRH)激发试验,依据激发实验结果将女童分为非CPP组和CPP组。运用统计软件对相关数据进行分析整合。 结果:(1)CPP组患儿晨尿LH、子宫长径均显著高于非CPP组,子宫动脉PI显著低于非CPP组(P<0.05)。(2)相关性分析结果表明,晨尿LH水平与晨尿FSH、子宫长径、横径、前后径、子宫容积、卵巢容积以及血清LH峰值、FSH峰值均呈正相关(P<0.05);子宫动脉PI与晨尿LH、晨尿FSH、子宫长径、横径、前后径、子宫容积、卵巢容积、血清LH峰值呈负相关(P<0.05),与血清FSH峰值无显著相关(P>0.05);子宫长径与晨尿LH、晨尿FSH、子宫横径、前后径、子宫容积、卵巢容积以及血清LH峰值均呈正相关(P<0.05),与血清FSH峰值无显著相关(P>0.05)。(3)ROC曲线分析晨尿LH、子宫动脉PI、子宫长径诊断女童CPP的曲线下面积(AUC)、灵敏度和特异度分别为 0.925、91%、84%,0.915、76%、90%,0.945、95%、88%。(4)晨尿LH、子宫动脉PI、子宫长径三项指标联合诊断女童CPP时,其AUC、灵敏度、特异度分别为0.974、98%、90.0%,优于单一指标。结论:晨尿LH、子宫动脉PI及子宫长径联合诊断女童CPP效能最高,且具有安全、无创、便捷等优点,适合临床推广应用。

    Abstract:

    Objective: To investigate the application value of morning urine combined with pelvic ultrasound and Doppler uterine artery imaging in the preliminary diagnosis of central precocious puberty (CPP) in girls. Methods: A total of 96 precocious girls admitted to the Department of Pediatrics, Huaian Clinical College, Xuzhou Medical University from April 2022 to May 2023 were selected as the study objects. Age, weight, height and other data of the children were collected, serum basic luteinizing hormone (LH) and estradiol levels were examined, morning urine LH and follicle stimulating hormone (FSH) were collected, and bone age was detected. At the same time, pelvic Doppler ultrasonography was performed to evaluate the uterine artery pulse index (PI), uterine long diameter, transverse diameter, anteroposterior diameter, and uterine volume and ovarian volume. The girls were divided into non-CPP group and CPP group according to the results of GnRH stimulation test. Statistical software was used to analyze and integrate relevant data. Results: (1) The levels of morning urine LH, FSH and uterine length diameter in CPP group were significantly higher than those in non-CPP group, and the uterine artery PI was significantly lower than that in non-CPP group (P < 0.05). (2) Correlation analysis results showed that morning urine LH level was positively correlated with morning urine FSH, uterine long diameter, transverse diameter, anteriorposterior diameter, uterine volume, ovarian volume, serum LH peak and FSH peak (P < 0.05). Uterine artery PI was negatively correlated with morning urine LH, morning urine FSH, long diameter, transverse diameter, anterior and posterior diameter, uterine volume, ovarian volume, and serum LH peak value (P < 0.05), but had no significant correlation with serum FSH peak value (P > 0.05). Uterine length diameter was positively correlated with morning urine LH, morning urine FSH, transverse diameter, anterior and posterior diameter, uterine volume, ovarian volume and serum LH peak value (P < 0.05), but had no significant correlation with serum FSH peak value (P > 0.05). (3) The area under the curve (AUC), sensitivity and specificity of ROC curve analysis of morning urine LH, uterine artery PI, and uterine length diameter for diagnosing CPP in girls were 0.925, 91%, 84%; 0.915, 76%, 90%; 0.945, 95%, 88%, respectively. (4) When morning urine LH, uterine artery PI and uterine length were combined in the diagnosis of CPP in girls, the AUC, sensitivity and specificity were 0.974, 98% and 90.0%, respectively, which was better than single index. Conclusion: The combination of morning urine LH, uterine artery PI and uterine length diameter has the highest efficacy in the diagnosis of CPP in girls, and has the advantages of safety, non-invasive and convenient, which is suitable for clinical application.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-07-02
  • 最后修改日期:2023-09-18
  • 录用日期:2023-10-18
  • 在线发布日期:
  • 出版日期: