Metabolic reprogramming is an important feature of tumor cells. Tumor cells reprogram metabolic pathways to meet the energy, materials and REDOX power required for rapid proliferation. Glucose metabolism, glutamine metabolism, lipid metabolism and one-carbon metabolism are important metabolic pathways of tumor. Targeting metabolism pathways can effectively inhibit tumor growth. This review summarizes the abnormal changes of glucose, fat, amino acid, nucleotide metabolism in lung cancer, as well as the latest exploration of related clinical drugs, aiming to provide new ideas for the prevention, early diagnosis and clinical treatment of lung cancer.