卵泡液外泌体在卵泡细胞功能调节中的机制研究进展
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南京医科大学第一附属医院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Research advances in follicular fluid exosomes as the regulator of follicular cell function
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    摘要:

    卵泡液是卵泡细胞生长发育的内环境,其中成分的变化与卵泡细胞的功能状态息息相关。近年来,人们发现在许多生物体液中都存在一种直径约为30-150nm的双层膜囊泡结构——外泌体(exosome),并揭示了它在众多生理病理过程中的媒介作用。研究者亦在卵泡液中鉴定出了外泌体成分,并发现它与卵泡细胞的生长发育有着密切的联系,并间接影响了卵母细胞状态,这对辅助生殖过程中部分评估卵母细胞质量有着重要意义。

    Abstract:

    Follicular fluid is the internal environment where follicular cells grow and proliferate, and the changes of its components are closely related to the functional status of follicular cells. In recent years, it has been found that exosome, a double-layer membrane vesicle with a diameter of about 30-150nm, exists in many biological fluids, and its mediating role in many physiological and pathological processes has been revealed. The researchers also identified exosomes in follicular fluid and found that they are closely related to the growth and proliferation of follicular cells, indirectly influencing oocyte status, which is important for partially assessing oocyte quality during assisted reproduction.

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历史
  • 收稿日期:2023-11-01
  • 最后修改日期:2023-11-20
  • 录用日期:2024-02-27
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