Glioblastoma multiforme (GBM) is the most common and malignant brain tumor in adults. The subventricular zone (SVZ), as the most concentrated site of adult neural stem cells, may be the potential source of glioblastoma stem cells. Studies have shown that SVZ plays an important role in the occurrence, development, recurrence and metastasis of the disease, and SVZ involvement can be used as a negative prognostic marker in GBM patients. Therefore, SVZ may be a target for radiotherapy in patients with glioblastoma. Moreover, SVZ radiotherapy can improve the prognosis of GBM, but there have been many contradictory research results in recent years. In order to explore the clinical value of SVZ, it is necessary to discuss the latest research progress between SVZ and radiotherapy. This review summarizes the relevant theoretical basis research, lists and evaluates the existing clinical evidence, and explores the value of SVZ radiotherapy.