心脏手术同期迷宫消融术后房颤复发的风险预测模型构建
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南京医科大学第一附属医院

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82100254


Construction of a risk prediction model for recurrence of atrial fibrillation after simultaneous maze ablation for cardiac surgery
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Jiangsu Province Hospital

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    摘要:

    摘要: 目的:探讨心脏手术同期行Maze IV消融治疗房颤术后复发的危险因素并构建其风险预测的列线图模型。 方法:收集2014年1月至2022年12月期间,南京医科大学第一附属医院心脏大血管外科收治的596例心脏手术同期行Maze IV消融的患者资料,统计患者基线、临床及手术等资料。本研究终点为房颤复发,定义为术后3月以后,出现新发房颤或心电图证实的持续时间大于30s的房速。所有患者均至少完成术后1年的随访,依据术后1年内是否房颤复发,将患者分为两组,比较两组患者资料,得出术后1年房颤复发的危险因素;使用COX多因素分析分析,得出房颤复发的独立危险因素,并构建房颤复发风险预测模型。 结果:596例患者中有263例(44.1%)为男性,中位年龄60岁,中位随访时间33个月,其中477例为持续性房颤,116例为阵发性房颤,3例为房扑。术后1年内,150例复发(25.2%),单因素分析显示:年龄、房颤持续时间、左房前后径(LAD)、右房前后径(RAD)、既往起搏器置入、早期房颤复发是术后房颤复发的危险因素;多因素分析显示:年龄、房颤持续时间、LAD、早期房颤复发为独立危险因素。COX回归分析得年龄(HR=1.035[1.016,1.055],P<0.001)、房颤持续时间(HR=1.003[1.001,1.006],P=0.003)、LAD(HR=1.025[1.006,1.044],P=0.009)、使用铰链式消融钳(HR=3.269[2.083,5.130],P<0.001)、术后早期房颤复发(HR=3.592[2.532,5.095],P<0.001)是房颤复发的独立危险因素。根据受试者特征曲线(ROC曲线)分析年龄、房颤持续时间、LAD的cut-off值分别为59.5岁、9.5月、51.5cm。基于COX结果,构建风险预测列线图。 结论:Maze IV在维持窦性心律方面具有良好的长期疗效。对于接受心脏手术的房颤患者,较大的年龄,较长的LAD、房颤持续时间会对消融结果产生不利影响,依据此结果构建的危险模型有良好的预测效能。

    Abstract:

    Abstract: Objective: Exploring the risk factors for postoperative recurrence of atrial fibrillation after concomitant Maze IV ablation for cardiac surgery and constructing a Nomogram model for risk prediction Methods: Data on 596 patients admitted to the Department of Cardiac Macrovascular Surgery of the First Affiliated Hospital of Nanjing Medical University for cardiac surgery with simultaneous Maze IV ablation were collected between January 2014 and December 2022, and baseline, clinical and surgical data of the patients were counted.The endpoint of this study was recurrence of atrial fibrillation, defined as the development of new-onset atrial fibrillation or electrocardiographically confirmed atrial tachycardia with a duration greater than 30 s after 3 months postoperatively. All patients were completed at least 1 year of postoperative follow-up and divided into two groups based on whether AF recurred within 1 year of surgery, comparing the data of the two groups and deriving the risk factors for AF recurrence at 1 year postoperatively.Independent risk factors for recurrence of atrial fibrillation are derived using COX multifactorial analysis and we construct a predictive model for the risk of recurrence of atrial fibrillation. Results: Of the 596 patients, 263 (44.1%) are male, with a median age of 60 years and a median follow-up time of 33 months. 477 patients are persistent atrial fibrillation, 116 are paroxysmal atrial fibrillation, and 3 atrial flutter.Within 1 year after surgery, there are 150 recurrences (25.2%). Univariate analysis show that age, duration of atrial fibrillation, left atrial anterior-posterior diameter (LAD), right atrial anterior-posterior diameter (RAD), previous pacemaker placement, and early atrial fibrillation recurrence are the risk factors for postoperative recurrence of atrial fibrillation, while multifactorial analysis show that age, duration of atrial fibrillation, LAD, and early atrial fibrillation recurrence are the independent risk factors.COX regression analyses yield significant differences in age (HR=1.047[1.025,1.068], P<0.001), AF duration (HR=1.004[1.001,1.006], P=0.002), LAD (HR=1.024[1.005,1.045], P=0.015), use of a hinged ablation forceps (HR= 3.445 [2.153,5.511], P<0.001), and early postoperative AF recurrence (HR=3.751 [2.616,5.379], P<0.001) are independent risk factors for AF recurrence.The cut-off values for age, AF duration, and LAD analysed based on the receiver operating characteristic curves (ROC curves) are 59.5 years, 9.5 months, and 51.5 cm, respectively.Based on the COX results, a Nomogram model is constructed. Conclusion: Maze IV has good long-term efficacy in maintaining sinus rhythm. In patients with atrial fibrillation undergoing cardiac surgery, older age, longer LAD, and duration of atrial fibrillation can adversely affect the ablation outcome, and the hazard model constructed on the basis of this result has good predictive efficacy.

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  • 收稿日期:2024-01-09
  • 最后修改日期:2024-04-22
  • 录用日期:2024-06-05
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