乳腺专用PET在乳腺癌中的临床应用进展
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南京医科大学第一附属医院核医学科

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国家卫生健康委核医学重点实验室、江苏省分子核医学重点实验室项目(KF202206)


Advances in the clinical application of dedicated breast PET in breast cancer
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Department of Nuclear Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu,China,210029

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    摘要:

    乳腺癌是目前世界范围内发病率最高的肿瘤,早发现、早诊断对于乳腺癌患者的治疗及预后具有重要意义。乳腺专用PET(dedicated breast PET, dbPET)是一种新兴的分子成像设备,近些年在临床实践中用于乳腺癌的检测和肿瘤生物学的评估。它具有比传统全身正电子发射型计算机断层显像/计算机体层成像(positron emission tomography/computed tomography, PET/CT)更高的空间分辨率,可以识别乳房内放射性示踪剂摄取的详细形态学模式。迄今为止,国内外对于dbPET的综合性分析较少,本文将从dbPET在乳腺癌的筛查、诊断、摄取模式、新辅助化疗后评估及PET显像剂等方面进行综述,以便对dbPET有一个比较系统的了解。

    Abstract:

    Breast cancer is currently the tumor with the highest incidence rate worldwide, and early detection and diagnosis are of great significance for the treatment and prognosis of breast cancer patients. Dedicated breast PET (dbPET)is an emerging molecular imaging modality, which has been used in clinical practice in recent years for the detection of breast cancer and the evaluation of tumor biology. It has higher spatial resolution than conventional whole-body PET/CT and can recognize detailed morphological attributes of radiotracer accumulation within the breast. So far, there are few comprehensive analysis of dbPET at home or abroad. In this paper, we will review dbPET in breast cancer screening, diagnosis, uptake patterns, post-neoadjuvant chemotherapy evaluation and PET tracers in order to have a more systematic understanding of dbPET.

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  • 收稿日期:2024-01-30
  • 最后修改日期:2024-03-04
  • 录用日期:2024-04-19
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