南京医科大学第二附属医院肿瘤医学中心
国家自然科学基金资助项目(82072591)
Cancer Medical Center,the Second Affiliated Hospital of Nanjing Medical University
长链非编码RNA（long non-coding RNA, lncRNA）是一类长度超过200nt的非编码RNA分子，大量研究报道其在恶性肿瘤的发生发展中发挥重要着重要的生物学功能。近年来，多项研究发现长链非编码RNA小核仁RNA宿主基因20（small nucleolar RNA host gene 20, SNHG20）在肺癌、肝癌、胃癌等多种肿瘤中高表达，促进肿瘤细胞的增殖、迁移、侵袭、EMT过程，抑制其凋亡，影响细胞周期进程，且与患者的预后不良相关。作为一个公认的致癌基因，lncRNA SNHG20是恶性肿瘤潜在的治疗靶点和评估预后的生物标志物。本文现总结国内外相关研究报道，对lncRNA SNHG20在恶性肿瘤中的研究进展作一综述。
Long non-coding RNA (lncRNA) is a class of non-coding RNA molecules with a length of more than 200nt, which has been reported to play an important role in the occurrence and development of malignant tumors. In recent years, a number of studies have found that long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) is highly expressed in a variety of carcinomas such as lung cancer, liver cancer and gastric cancer, promoting the proliferation, migration, invasion and EMT process of tumor cells, and inhibiting their apoptosis, it affects cell cycle progression and is associated with poorer prognosis of patients. As a recognized oncogene, lncRNA SNHG20 is a potential therapeutic target for malignant tumors and a biomarker for evaluating prognosis. In this article, we summarize relevant research reports around the world, and review the research progress of lncRNA SNHG20 in cancer.