南京医科大学附属儿童医院
国家自然科学基金项目（面上项目，重点项目，重大项目）
目的:利用静息态功能磁共振（resting state functional MRI,rs-fMRI）探讨7-15岁不同程度肥胖儿童大脑局部一致性（regional homogeneity,ReHo）的特征。方法:选取单纯性肥胖儿童（Obesity, OB）35例、肥胖伴有代谢综合征儿童（Metobolic Syndrom, MS）20例及健康儿童（Healthy Controls, HC）24例，均进行rs-fMRI扫描，计算ReHo值并对比三组之间的差异，而后将差异脑区与临床资料进行相关性分析。结果:与HC组相比，OB组及MS组右侧梭状回、左侧颞下回的ReHo值升高，右内侧额上回、左背外侧额上回的ReHo值降低；与OB组相比，MS组左背外侧额上回ReHo值降低，且左背外侧额上回的ReHo值与丙氨酸氨基转移酶（alanine aminotransferase，ALT）、天冬氨酸氨基转氨酶（aspartate aminotransferase，AST）呈显著负相关（r=-0.3498 ,P=0.0089;r=-0.2944, P=0.0291）。均P<0.05。结论 肥胖儿童在参与摄食调节、抑制控制等脑区功能活动异常，左背外侧额上回的活动异常与肥胖程度相关，可为早期干预和治疗提供影像学依据。
Objective: To observe the feature of brain regional homogeneity (ReHo) in children with different degrees of obesity aged 7-15 years by resting state functional magnetic resonance imaging (rs-fMRI). Methods: Resting-state fMRI data were collected from 35 cases obesity children (OB), 20 cases obesity children with metabolic syndrome (MS), and 24 cases healthy children (HC). The data were analyzed,and ReHo differences among the three groups were compared. Then the correlation between the different brain regions and clinical data was analyzed. Results: Compared with HC group, the ReHo values of right fusiform gyrus and left inferior temporal gyrus in OB and MS groups were higher. The ReHo values of right medial superior frontal gyrus and left dorsolateral superior frontal gyrus decreased. Compared with OB group, the ReHo value of left dorsolateral superior frontal gyrus in MS group was lower. The ReHo values of left dorsolateral superior frontal gyrus were negatively correlated with ALT and AST transaminase(r=-0.3498,P=0.0089; r=-0.2944,P=0.0291).(all P<0.05). Conclusion: Obese children have abnormal functional activity in brain areas such as participating in feeding regulation and inhibitory control, and the abnormal activity in the left dorsolateral superior frontal gyrus is associated with the degree of obesity, and to provide imaging evidence for early intervention and treatment.
