释氧生物材料用于组织工程的研究进展
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1.宁波大学医学部;2.宁波市医疗中心李惠利医院

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基金项目:

浙江省自然科学基金(LQ21H060002);宁波市自然科学基金(2022J251)


Research progress of oxygen-releasing biomaterials for tissue engineering
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Affiliation:

1.Ningbo University Health Science Center;2.Li Huili Hospital, Ningbo Medical Center

Fund Project:

Natural Science Foundation of Zhejiang Province, No. LQ21H060002; Natural Science Foundation of Ningbo City (2022J251)

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    摘要:

    一定程度的局部缺氧会引起不同水平的组织细胞损伤,释氧生物材料能持续给移植细胞供氧。近年来,许多研究致力于开发出更有应用价值的释氧生物材料和体系,来增加体内的氧气输送,以保证植入组织的有效氧供。根据提供氧气的形式可以分为携氧材料和产氧材料。前者基于特定条件下结合氧分子后提供治疗性氧合,后者则是借助氧源材料组合入聚合物内,通过在体内的水解达到氧气释放的效果。本文在归纳和总结了携氧材料发展现状与产氧材料的氧源供应、装载材料和控制释放等多方面的最新研究,论述了释氧生物材料进行氧气递送的实践应用和控制缓释的一系列方案。

    Abstract:

    Some degree of localized hypoxia can cause varying degrees of tissue cell damage, and oxygen releasing biomaterials can provide continuous oxygen delivery to transplanted cells. In recent years, extensive research efforts have been dedicated to the advancement of valuable oxygen-releasing biomaterials and systems, with the aim of enhancing oxygen delivery within the body, thus ensuring effective oxygen supply to implanted tissues. Oxygen-carrying and oxygen-producing materials can be categorized according to the mode of oxygen delivery. The former are based on the binding of oxygen molecules under specific conditions to provide therapeutic oxygenation, while the latter are based on the combination of oxygen source materials into polymers that are hydrolyzed in vivo to achieve the effect of oxygen release. This paper summarizes the current development of oxygen-carrying materials and the latest research on oxygen-producing materials in terms of oxygen delivery, carrier materials and controlled release, and discusses the practical application of oxygen-releasing biomaterials for oxygen delivery and a number of schemes for controlling slow release.

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  • 收稿日期:2024-05-31
  • 最后修改日期:2024-07-09
  • 录用日期:2024-08-30
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