As the most common metabolic disease, diabetes is closely related to cardiovascular disease and is an independent risk factor for acute myocardial infarction. Nuclear factor erythroid-2-related factor 2 (NRF2) is the key to cellular antioxidant response, which can increase the transcription of downstream antioxidant genes by interacting with other proteins and binding to antioxidant response elements and maintain redox homeostasis.Some studies have shown that NRF2 is involved in the regulation of the occurrence and development of diabetic myocardial ischemia-reperfusion injury, but its mechanism is not fully understood. This paper mainly reviews the research progress of NRF2 signaling pathway related to diabetic myocardial ischemia-reperfusion injury and NRF2 targeted therapy, providing new ideas for the clinical treatment of diabetic myocardial ischemia-reperfusion injury.