Objectives: To evaluate the effect of non-curative ESD(endoscopic submucosal dissection, ESD) on postoperative complications after additional esophagectomy and the appropriate time interval between non-curative ESD and additional esophagectomy. Methods: Between october 2019 and october 2022, 831 patients with esophageal cancer undergoing minimally invasive?McKeown?esophagectomy were enrolled in this study. Patients were divided into two groups according to whether non-curative ESD was performed before esophagectomy. Ater 1∶3 matching through propensity score matching (PSM), 201 patients were included , with 52 patients in the ESD+OP group and 149 patients in the Non-ESD+OP group. Postoperative complications were compared between the two groups and the effect of the time interval between two operations on the postoperative complications were evaluated. Results: A significant difference was found in the frequence of postoperative complications between the two groups (60% : 33%，P＝0.01). The ESD+OP group had higher rate of pulmonary infection(13% : 2%, P=0.001) and anastomotic fistula(13% : 2%, P=0.033) compare to the Non-ESD+OP group. Compared to the other weeks, the risk of postoperative complications was lower in patients received esophagectomy within 2-4 weeks after ESD (38% : 74%, P=0.033). Conclusions: The non-curative ESD may increased the postoperative complications and the risk of esophagectomy. A appropriate time interval（2-4 weeks）between non-curative ESD and esophagectomy may reduce the risk of esophagectomy and benefit the patients.