癌症相关成纤维细胞在乳腺癌转移中的研究进展
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南京医科大学附属苏州医院(苏州市立医院)甲乳外科

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江苏省妇幼保健重点学科(0023); 苏州市科技局科研项目医疗卫生科技创新-医学创新应用研究(SKY2022193)


Research progress of cancer-associated fibroblasts in breast cancer metastasis
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Department of Thyroid and Breast Surgery, the Affiliated Suzhou Hospital of Nanjing Medical University(Suzhou Municipal Hospital)

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Key Disciplines of Maternal and Child Health Care in Jiangsu Province (0023); Suzhou Science and Technology Bureau Scientific Research Project Healthcare Science and Technology Innovation-Medical Innovation Application Research (SKY2022193)

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    摘要:

    癌症相关成纤维细胞(Cancer-associated fibroblasts, CAFs)主要来源于静止的正常成纤维细胞,部分起源于间充质干细胞、上皮细胞以及内皮细胞。作为肿瘤微环境(Tumor microenvironment, TME)中的重要组成部分,在乳腺癌的转移过程中发挥关键作用。近年来,研究者们愈发关注CAFs的生物学特性及其与乳腺癌细胞之间的相互作用。CAFs通过分泌多种细胞因子和外泌体微小RNA(microRNA, miRNA)、改变细胞外基质成分、调节细胞间信号传递以及重塑TME,促进乳腺癌细胞的侵袭和转移。尽管已有大量研究揭示了CAFs在乳腺癌转移中的重要性,但其具体作用机制仍需进一步探讨。本文将系统性综述CAFs在乳腺癌转移中的最新研究进展,探讨CAFs在其中的核心机制和功能,以期为未来的研究提供新的思路。

    Abstract:

    Cancer-associated fibroblasts (CAFs) are mainly derived from quiescent normal fibroblasts, and partially originated from mesenchymal stem cells, epithelial cells and endothelial cells. As an important part of the tumor microenvironment (TME), CAFs play a key role in the metastatic process of breast cancer. In recent years, researchers have paid more attention to the biological properties of CAFs and their interactions with breast cancer cells, which promote breast cancer cell invasion and metastasis by secreting various cytokines and exosomal microRNA (miRNA), altering extracellular matrix compositions, regulating intercellular signaling, and remodeling the TME. Although a large number of studies have revealed the importance of CAFs in breast cancer metastasis, their specific mechanisms of action need to be further explored. In this paper, we will systematically review the latest research progress of CAFs in breast cancer metastasis, and explore the core mechanism and function of CAFs in it, with a view to providing new ideas for future research.

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  • 收稿日期:2025-05-20
  • 最后修改日期:2025-08-06
  • 录用日期:2025-09-23
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