Objective: To analyze and compare the changes in the incidence trends of four types of hepatitis in Jiangsu Province and the national level, reveal the regional characteristics and current status of hepatitis incidence in Jiangsu Province, and provide reference for hepatitis prevention and control work both in Jiangsu Province and nationwide. Methods: Descriptive epidemiological methods, annual average change percentage and time-space scanning statistical methods were used to analyze and compare the incidence data of four types of hepatitis (hepatitis A, B, C and E) in Jiangsu Province and the national level from 2004 to 2022. Results: The average incidence rates (1/ 100,000) of four types of hepatitis in Jiangsu Province and nationwide from 2004 to 2022 were 1.55 and 2.72 for hepatitis A, 18.70 and 75.24 for hepatitis B, 3.50 and 11.85 for hepatitis C, and 3.80 and 1.77 for hepatitis E, respectively. The change trend of incidence rate in recent years is as follows: in the nationwide, hepatitis A remained a stable trend (2012 – 2022，P>0.10), hepatitis B remained a steady trend (2014-2022，P>0.5), hepatitis C displayed a downward trend (2019-2022, P<0.001), and hepatitis E remained a stable trend (2013-2022, P>0.5); In Jiangsu Province, hepatitis A remained a stable trend (2013-2022, P>0.20), hepatitis B showed an upward trend (2012-2022, P <0.05), hepatitis C showed an upward trend (2004-2022, P<0.001), and hepatitis E demonstrated a declining trend (2011-2022, P<0.001); the statistical analysis of time-space scanning shows that three low-incidence clusters for Hepatitis A in nationwide all included Jiangsu Province, one of three low-incidence clusters for Hepatitis B included Jiangsu Province, two of four low-incidence clusters for Hepatitis C included Jiangsu Province, and all three high-incidence clusters for Hepatitis E included Jiangsu Province. Conclusion: From 2004 to 2022, in the nationwide, the highest average incidence rate of hepatitis was for Hepatitis B, followed by Hepatitis C, Hepatitis A, and Hepatitis E. In Jiangsu Province, Hepatitis B also had the highest average incidence rate, followed by Hepatitis E, Hepatitis C, and Hepatitis A, the average incidence rates of Hepatitis A, B, and C in Jiangsu Province were lower than the national average, while that of Hepatitis E was higher than the national average. The national hepatitis prevention and control strategy should prioritize reducing the incidence of Hepatitis B and shifting the stable trends of Hepatitis A and Hepatitis E to downward trends. In Jiangsu Province, the strategy should focus on lowering the incidence of Hepatitis B and Hepatitis E, reversing the upward trends of Hepatitis C, and transforming the stable trend of Hepatitis A into a downward trend.