Objective: To evaluate the efficacy and safety of gastroscopic biopsy forceps repositioning technique in peritoneal dialysis (PD) catheter drift. Methods: A retrospective analysis was conducted on clinical characteristics of PD catheter drift patients in the First Affiliated of Nanjing Medical University from January 2014 to December 2024. The technical success rate, procedure durations, cost, and complication rate were compared between conservative treatment, gastroscopic biopsy forceps repositioning and surgery repositioning. Results: Patients with catheter drift initially received conservative treatment, which achieved a success rate of 11.76% (2 out of 17). One patient requested laparoscopic repositioning, which was 100% successful (1 out of 1) at a cost of 3,000 yuan. The remaining 14 patients underwent gastroscopic biopsy forceps repositioning, with a success rate of 85.71% (12 out of 14). The procedure time for this method was 24.00 ± 6.65 minutes, and the cost was 130 yuan. The two patients who failed gastroscopic biopsy forceps repositioning had a long history of catheters placement over two years. They subsequently underwent successful open surgical repositioning, with a procedure time of 60 minutes and a cost of 400 yuan. No severe complications occurred in any of the cases, and all patients resumed dialysis function within 24 hours postoperatively. Conclusion: Gastroscopic biopsy forceps repositioning technique is a safe, cost-effective, and minimally invasive technique for PD catheter drift, with no radiation exposure.