Objective: To evaluate the impact of individualized nutritional intervention by a multidisciplinary team (MDT) based on nutritional risk assessment on short-term (3 months) nutritional status, liver function, and serum liver fibrosis markers in patients with cirrhosis.Methods: A total of 60 patients with cirrhosis admitted to Gaoyou People's Hospital from May 2023 to May 2025 were selected and divided into a control group (conventional nutritional management, n=30) and an intervention group (conventional nutritional management combined with MDT nutritional intervention based on nutritional risk assessment, n=30) using a random number table. Both groups of patients received appropriate nutritional intervention on day 1 of admission. To reduce the impact of fluid fluctuations and acute stress on laboratory indicators in the early stages of admission, blood samples taken in the morning of day 2 of admission and physical measurements were used as the baseline (T0). Follow-up was conducted at 1 month (T1) and 3 months (T2) after discharge. The observed indicators included nutritional status (body mass index (BMI), hemoglobin (Hb), serum albumin (ALB), prealbumin (PA)), liver function (alanine aminotransferase (ALT), prothrombin time (PT), total protein (TP)) and liver fibrosis indicators (type IV prothrombin IV-C, hyaluronic acid HA, laminin LN, type III prothrombin PCIII) were evaluated on the second day, one month and three months after admission. Mixed linear models were used to analyze the differences and changing trends of each indicator between the two groups at different time points. Results: The examination results of the patients showed that the levels of BMI, Hb, ALB and PA in the intervention group were higher than those in the control group (P<0.05); the levels of ALT, PT, IV-C, HA, LN and PCIII were lower than those in the control group (P<0.05). Mixed linear model analysis showed that the improvement rate of each index in the intervention group was significantly faster than that in the control group, and the interaction effect between group and time was significant (P<0.01). Conclusion: Nutritional intervention based on nutritional risk assessment (MDT) can effectively improve the short-term nutritional status, liver function, and serum liver fibrosis markers in patients with cirrhosis. However, the follow-up period of the study was short, and long-term clinical outcomes cannot be inferred at this time.