表皮生长因子受体、C-erbB-2原癌基因在乳腺癌组织中的表达及其与乳腺癌骨髓微小转移的关系
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Expression of EGFR, C-erbB-2 Proteins in Breast Cancer and Relation with Microme- tastasis in Bone Marrow
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    摘要:

    目的 观察乙醇对伏核神经元电活动的影响,探讨乙醇的中枢作用机制及与内源性阿片肽的关系。方法 制备大鼠伏核脑片,采用细胞外记录。结果 ⑴单独灌流乙醇(0.2μmol/L)使神经元放电频率先增加后降低,并可被Nal(0.2μmol/L)翻转。⑵联合灌流阿片受体特异性激动剂DAGO、U-50、D-PEN(0.5μmol/L)和乙醇,神经元抑制程度增强,以DAGO最为显著。结论 乙醇抑制伏核神经元电活动,

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    Objective To investigate the expression of epidermal growth factor receptor (EGFR) and C-erbB-2 proteins in breast cancer, and to search the relation between micrometastasis in bone marrow and the above facts. Methods SABC immunocytochemical assay for EGFR and C-erbB-2 proteins were made on paraffin embedded section. The statistical analyses were performed using chi-square test. Results Overall, 42.9%of the tumors were EGFR proteins positive.C-erbB-2 proteins were positive in 31%of the tumors. The positivity of both EGFR and C-erbB-2 proteins was significantly connected to that of micrometastasis in bone marrow. The positivity of EGFR proteins was not related to that of C-erbB-2 proteins. The follow-up period of 26 patients was 60 months. The overall survival was worse in patients with EGFR, C-erbB-2 proteins positive tumors compared with EGFR, C-erbB-2 proteins negative tumors. Conclusion EGFR, C-erbB-2 proteins are significantly related to micrometastasies in bone marrow. Multivariate analyses show that both EGFR and C-erbB-2 proteins positive are two key prognostic factors in breast cancer patients.

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蔡昌抨,武正炎,郑伟.表皮生长因子受体、C-erbB-2原癌基因在乳腺癌组织中的表达及其与乳腺癌骨髓微小转移的关系[J].南京医科大学学报(自然科学版),2000,20(01):

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