Objective To study and evaluate the probability of bBMP-albumin-bFGF composite materials in repairing bone defect of cleft palate. Methods On the basis of animal model of cleft palate bone defects in rabbits, composite materials (bBMP-albumin-bFGF) and single albumin were first used to repair the cleft palate bone defect respectively in rabbits, involving new bone formation and repairing bone defect by their induction effects. Results The results of X-ray, histological examination and calcium content check proved that bBMP-albumin-bFGF has strong effects of bone induction. It was able to involve induction of new bone formation in quality and quantity and repair palate bone defect in rabbits. Conclusion There is a promising prospect in use of bBMP-albumin-bFGF as a bone defect repairing meterial of cleft palate.