系统性红斑狼疮患者血清IL-1,SIL-2R,IL-6,IL-8的变化及临床意义
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Changes in the Serum levels of IL-1,SIL-2R,IL-6 and IL-8 in Patients with Systemic Lupus Erythematosus and Its Clinic Significance
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    摘要:

    目的 观察酶酚酸酯(骁悉,MMF)在预防肾移植信后近期(3个月)急性排斥反应的情况。方法 选择尸肾移植患者112例,随机分成两组:MMF(2.0g/d)组和硫唑嘌呤(AZA)组,两组患者均同时接受相似剂量的环孢霉素A(CsA)和类固醇激素治疗。结果 观察3个月,急性排斥发生率,MMF组60例,为16.6%(10/60);AZA组52例,为41.5%(22/52);两组差异显著(P〈0.01)。MM

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    Objective To evaluate the relationship between cytokines and the active systemic lupus erythematosus(SLE). Methods 46 cases with active SLE were graded in three levels (minor, medium ,serious) and grouped into two (LN, non-LN). Serum levels of IL-1,SIL-2R,IL-6 and IL-8 were measured by using ELISA method. Results The serum levels of IL-1,SIL-2R,IL-6 and IL-8 in SLE patients were enhanced significantly as compared to the normal control, and the serum levels of cytokines had a positive correlation with the active SLE. Furthermore, the serum levels of SIL-2R, IL-6,IL-8 from LN patients were higher than that from non-LN patients. Conclusion These results suggest that the abnormally enhanced cytokines disturb the immunity network and cause immunity damage. Thus, Measuring serum cytokines is important in clinic therapy in recognizing the degrees of SLE activity.

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武正炎,范萍,俞悦,赵中辛,丁友成,沈友轩,顾镭.系统性红斑狼疮患者血清IL-1,SIL-2R,IL-6,IL-8的变化及临床意义[J].南京医科大学学报(自然科学版),2000,20(01):

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