不同子宫内膜组织层粘连蛋白的表达及其意义
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The Expression and Significance of Laminin of Three Different Endometrium
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    摘要:

    观察层粘连蛋白(laminin,LN)在正常子宫内膜、子宫内膜增殖症和子宫内膜癌中的表达规律,了解LN表 达与子宫内膜癌发生及发展的关系。方法 用免疫组化LSAB法检测了16例正常子宫内膜、12例子宫内膜增殖症、27例子宫 内膜癌组织中LN的表达。结果 3组内膜组织腺上皮基膜、腺细胞与间质细胞质内均有LN表达。其中3组内膜间腺上皮基膜 LN表达构成比(X2=13.06,P<0.001)、腺细胞LN表达率(X2=17.82,P<0.001)、间质细胞LN表达率(X2=1 6.95.P< 0,001)、腺细胞/间质细胞LN表达构成比(X2=27.49,P

    Abstract:

    vTo investigate the expression of laminin(LN) on normal endometrium, hyperplastic en dometrJum and endometrlal adenocarcinoma and; to study the relationship between LN's expression and endometrial adenocarcinoma. Methods LSAB immunohistoehemical method was used to study LNts expression on 16 normal, 12 hyperplastic and 27 adenocarcinoma endometrium cases. Results Laminin is widely expressd on epithelia basement membrane(EBM), epithelial/cancer cell(EC) and stromal cell (SC). Among normal, hyperplastie, adenocarcinoma endometrium, LN's expression on EBM (X2=13.06,P<0. 001), EC (X2= 17.82,P<0. 001), SC (X2=16.96,P <0. 01) and EC/SC (X2=27.49,P<0. 001) are significantly different. The LN's expression was compared with clinical and pathologic parameter of endometrial adenoeareinoma, and the clinical stages of endometrial adenocarcinoma compared with LNts expression on EBM (P<0. 05) and on SC (P<0. 01) ,and the pathologic grades of endame trial adenocarcinoma with LN's expression on SC (P<0.05), all those being different in statistics. Conclusion The LN's expression on epithelial/cancer cells and disapearane on epithelial basement membrane, stromal cells are related to endometrial carcinoma; It may be an important sign on the early stage of endometrlal adenocarcinoma.

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吴霞,皋岚湘,郑漪霖,王淑玉,赵君利.不同子宫内膜组织层粘连蛋白的表达及其意义[J].南京医科大学学报(自然科学版),2000,20(03):

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