膀胱移行细胞癌Ki-67的表达及其意义
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Expression and Significance of Ki-67 in Transitional Cell Carcinoma of Bladder
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    摘要:

    人类细胞核抗原(Ki-67)特异性地存在于细胞周期除G0期以外的各个阶段(G、S、G2和M期),被广泛地 用于多种人类肿瘤增殖活性的评估。探讨Ki-67的表达与膀胱移行细胞癌(TCC)生物学行为的关系。方法 33例膀胱TCC石 蜡块标本均经病理复检,12例正常膀胱组织作为对照组。免疫组织化学染色方法为SP法。结果 Ki-67阳性表达率TCC组为 54.55%(18/33),对照组为8.33%(1/12,P<0.01):Ki-67指数与肿瘤的分期、分圾相关(P<0.001,P

    Abstract:

    Ki-67 is exclusively present in all stages of cell cycle (C1, S, C2 and mitosis)except for G0, and widely used to determine proliferative activity of various tumors. The relativity of expression of Ki-67 and the biological behaviour of transitional cell carcinoma (TCC) of bladder was evaluated in the study. Methods The paraffin embedded tissue sections from 33 patients with TCC of bladder were reexamined. According to the UICC standard, 21 cases had surperficial tumors and 12 cases had invasive tumors. With the pathological diagnostic standard of WHO, there were 16 cases of G1 , 10 cases of G2 and 7 cases of G3. Meanwhile, there were 21 cases with primary lesions and 12 cases with recurrent lesions. 12 specimens obtained from normal bladders were used as controls. Expres sion of gA 67 was detected by streptavidin-peroxidase (SP) immunohistochemical technique. Results Expression of gA-67 was found in 54. 5%(18/33) of TCCs and 8. 33%(1/12) of controls (P

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眭元庚,吴宏飞,宋旭.膀胱移行细胞癌Ki-67的表达及其意义[J].南京医科大学学报(自然科学版),2000,20(03):

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