Objective： To establish the bronchial asthma model in sprague dawley（SD） rat. Methods： Twenty-four SD rats（SPF）were randomly divided into normal control group and asthmatic model group，12 rats per group. The asthmatic model of SD rats were established by immunization with intraperitoneally injected and inhaled ovalbumin（OVA）. The bronchial provocation test by acetylcholine was used in each group. Expiratory airway resistance（Re）was measured by using animal respirator. The thicknesses of WA／Pi，ASM／Pi，and the numbers of eosinophils and lymphocytes were measured. Results： Through the comparison of Re，the thicknesses of WA／Pi and ASM/Pi， and the numbers of eosinophils of each group， the modeling method was confirmed to be successful. The analysis of correlation indicated that Re of asthmatic model group was positively correlated with the thicknesses of WA／Pi and ASM／Pi and the numbers of eosinophils and lymphocytes while challenged by acetylcholine（80 μg／kg and 160 μg／kg）. Conclusion： The bronchial asthma model in SD Rat might be established successfully. The success of the modeling method might be evaluated directly by the concentration doubling of Re， while challenged by acetylcholine of 80 μg／kg and 160 μg／kg.