Objective： To review the clinical experience in surgical treatment for Tetralogy of Fallot in adults over 15 years old. Methods：From October 1997 to January 2006，50 patients over 15 years old（15-57 years） underwent corrective repairment for Tetralogy of Fallot. Ventricular septal defects were repaired with Dacron patches in all patients. Forty-one cases were operated to widen the right ventricular outflow with patches and 9 cases underwent single repairment of right ventricular outflow. Results：One patient died from severe low cadiac output syndrome after operation. Heart functions and clinical manifestations were improved significantly in other patients. Conclusion：Proper surgical correction and careful perioperative management play an important role in the treatment of Tetralogy of Fallot in adults.