细胞色素P450 2E1基因多态性、烟酒习惯与直肠癌易感性的关系
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国家自然科学基金重大国际(地区)合作研究项目(30320140461)和日本文科省国际学术研究癌症特别研究经费项目(08042015)资助


Relationship of CYP2E1 RsaⅠ genetic polymorphism and smoking,alcohol drinking habit with risk of rectal cancer
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    目的:研究细胞色素P450 2E1(CYP2E1)基因RsaⅠ多态性、烟酒习惯与直肠癌遗产易感性的关系。方法:在江苏省进行病例-对照研究(直肠癌患者210例,人群对照439例),调查研究对象的生活习惯,抽取静脉血,提取白细胞DNA,采用PCR-RFLP 检测研究对象的CYP2E1 RsaⅠ位点基因型。结果: CYP2E1 RsaⅠ c1/c1、c1/c2和c2/c2基因型分布频度在直肠癌组分别为58.4%、34.0%和7.7%,对照组分别为61.4%、35.6%和3.0%,两组之间差异有显著性(χ2MH = 7.07,P = 0.029)。在调整性别、年龄、吸烟和饮酒习惯后,CYP2E1 c2/c2基因型携带者与c1/c1基因型者相比,发生直肠癌的危险性显著升高(OR = 1.64,95% CI:1.12~2.41)。多因素分析结果显示,有饮酒习惯者发生直肠癌的危险性显著升高,其调整后OR为2.08(95% CI:1.36~3.19),而吸烟与增加或降低直肠癌的危险性无显著相关。CYP2E1基因多态与吸烟、饮酒相互作用的分层分析发现,在不吸烟者中,c2/c2基因型者与c1等位基因型者相比,发生直肠癌的危险性显著上升(性别和年龄调整OR = 2.30,95%CI:1.32~3.99);在饮酒者中, 携带c2/c2基因型者发生直肠癌的调整OR为5.75(95%CI:1.65~20.05),提示CYP2E1 RsaⅠ多态与饮酒习惯有显著的协同作用。结论:CYP2E1 RsaⅠ基因多态和饮酒习惯影响直肠癌的易感性,二者在直肠癌发生中有显著的协同作用。

    Abstract:

    Objective: To study the relationship between genetic polymorphism of cytochromes P4502E1 RsaⅠand smoking,alcohol drinking habit with the susceptibility of rectal cancer. Methods:A case-control study was conducted with 210 cases of rectal cancer and 439 population-based controls in Jiangsu Province, China. The epidemiological data were collected, and DNA of peripheral blood leukocytes was obtained from all the subjects. CYP2E1 RsaⅠgenotypes were detected by PCR-RFLP. Results:The frequencies of CYP2E1 RsaⅠ c1/c1,c1/c2 and c2/c2 genotypes were 58.4%, 34.0% and 7.7% in rectal caner cases, compared with 61.4%, 35.6% and 3.0% in controls(χ2 = 7.07, P = 0.029). Individuals with CYP2E1 RsaⅠ c2/c2 genotype were at an increased risk of rectal cancer(adjusted for age, sex and status of the smoking and alcohol drinking,OR = 1.64, 95% CI:1.12-2.41) compared with those with CYP2E1 RsaⅠ c1/c1 genotype. Individuals who had alcohol drinking habit were at an increased risk of rectal cancer(adjusted OR = 2.08, 95% CI:1.36-3.19), whereas smoking was not associated with risk of rectal cancer. There was a significantly cooperated effect between CYP2E1 RsaⅠ polymorphism and alcohol drinking habit in the risk of rectal cancer. The risk of rectal cancer of individuals with CYP2E1 RsaⅠ c2/c2 genotypes and drinking habit increased 5.75 times(95%CI:1.65-20.05). Conclusion:Polymorphisms of the CYP2E1 RsaⅠ and acohol drinking have effects on rectal cancer and have significantly synergic effect.

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龚建平,高长明,Takezaki Toshiro,吴建中,陈敏斌,曹海霞,曹 佳,Hamajima Nobuyuki, Tajima Kazuo,周建农.细胞色素P450 2E1基因多态性、烟酒习惯与直肠癌易感性的关系[J].南京医科大学学报(自然科学版),2006,(12):1163-1167

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  • 收稿日期:2006-05-15
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