肝细胞性肝癌中MCP-1的表达与血管新生的关系
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Correlation of MCP-1 expression with angiogenesis in hepatocellular carcinoma
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    摘要:

    目的:检测MCP-1在肝细胞性肝癌中表达的状况,分析其与肿瘤血管新生的关系。方法:制作包含36例非肿瘤肝疾病和109例肝细胞性肝癌(HCC)肿瘤及癌旁组织的组织芯片,运用免疫组化的方法检测MCP-1,VEGF,CD68的表达情况;运用CD34标记肿瘤血管,进行微血管密度计数。结果:MCP-1在HCC,癌旁和非肿瘤肝疾病中的表达率分别为40.4%、67.0%和44.4%。HCC中MCP1与VEGF(r = 0.233,P = 0.015)和微血管密度(MVD,r = 0.234,P = 0.014)均有相关性,MCP-1的表达情况与肿瘤的病理分期亦有相关性(P < 0.05),而与肿瘤的大小,数目,分化,肝硬化和预后无显著相关性。结论:MCP-1通过诱导VEGF的表达增强促进HCC血管新生,但MCP-1不能作为提示HCC预后的指标。

    Abstract:

    Objective:To investigate the expression of monocyte chemoattractant protein-1(MCP-1) in hepatocellular carcinoma (HCC) and the clinical significance. Methods:Tissue microarray(TMAs) including 36 specimens of non-tumor liver disease and 109 specimens of HCC(containing tumor tissue and adjacent non-cancerous tissue) were prepared. MCP-1, VEGF and CD68 were detected with immunohistochemistry method. Blood capillaries stained for CD34 were counted in HCC, and microvessel density (MVD) was determined. Results:The expression rate of MCP-1 cancer cells, adjacent non-cancerous tissues and non-tumor liver diseases was 40.4%, 67.0% and 44.4% respectively. The expression of MCP-1 was correlated with that of VEGF(r = 0.233,P = 0.015) and MVD(r = 0.234,P = 0.014). MCP-1 expression in TMAs was significantly correlated with the pathological stage(P < 0.05), but not with tumor size, tumor number, blood vessel invasion, differentiation, cirrhosis and prognosis. Conclusion:MCP-1 may play an important role in HCC angiogenesis through inducing the production of angiogenic factors, such as VEGF. But the expression of MCP-1 in HCC can’t be regarded as an indicator of prognosis.

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陈 骏,孙喜太,丁义涛,孟凡青,吴鸿雁.肝细胞性肝癌中MCP-1的表达与血管新生的关系[J].南京医科大学学报(自然科学版),2007,(2):133-136141

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  • 收稿日期:2006-06-15
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