Objective：To investigate the effects of Ｖalsartan on the expression of monocyte chemoattractant protein-1（MCP-1） in the arteria of STZ-induced diabetic rats. Methods：SD rats were randomly divided into NC group，DM group and DV group. Blood glucose（BG）, body weight（BW）, and HbA1c were observed. the expression of MCP-1 in the arteria of diabetic rats was detected by RT-PCR and Western blot at the 8 th week. Results：The BW of diabetic rats in DM and DV groups decreased significantly compared with NC group（P < 0.01）, but no notable difference was found in HbA1c and BG between DM and DV group（P > 0.05）. The expression of MCP-1 mRNA in DM and DV groups was much higher than that in NC group（P < 0.01）, but it was much lower in DV group than that in DM group（P < 0.01）. The expression of MCP-1 protein in DM and DV groups was much higher than that in NC group（P < 0.01）, and it was much lower in DV group than that in DM group（P < 0.01）. Conclusion：The expression of MCP-1 is much higher in the arteria of diabetic rats. Valsartan could obviously reduce the expression of MCP-1 in the arteria of diabetic rats and ameliorate the inflammation in the arteria.