食管鳞癌和淋巴结组织Paxillin和CD44v6的表达与临床意义
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Expression and clinical significance of paxillin and CD44v6 proteins in esophageal squamous carcinoma and lymph node tissue
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    目的:研究桩蛋白(Paxillin)和CD44v6在食管鳞癌组织中的表达及其与食管鳞癌细胞侵袭与转移的关系。方法:应用免疫组化SP法检测24例正常食管黏膜、94例食管鳞癌和83例淋巴结中Paxillin和CD44v6的表达情况。结果:原发癌组织中Paxillin表达率与浸润深度(P < 0.01)、临床分期(P < 0.01)和淋巴结转移(P < 0.05)等因素有关;CD44v6表达率与浸润深度(P < 0.05)、临床分期(P < 0.01) 和淋巴结转移(P < 0.05)等因素有关;原发癌组织和转移淋巴结组织中Paxillin和CD44v6表达率均高于无转移淋巴结组织(P < 0.05); Paxillin和CD44v6在淋巴结组织中表达无相关性(P > 0.05)。结论: Paxillin和CD44v6在食管癌组织和转移淋巴结中高表达,在食管癌的发生、发展过程中具有重要作用,可作为评价食管癌生物学行为的指标。

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    Objective:To study the expression of paxillin and CD44v6 in esophageal carcinoma and to investigate the relationship between the expression of paxillin and CD44v6 and invasion and metastasis of esophageal carcinoma. Methods:Paxillin and CD44v6 expression were detected in 24 normal esophageal mucosa, 94 primary tumor tissues and 83 lymph nodes by SP immunohistochemical method. Results:The positive expression rate of paxillin in primary tumor tissues was related with invasive depth(P < 0.01), clinical staging(P < 0.01) and metastasis of lymph node(P < 0.05). The positive expression rate of CD44v6 in primary tumor tissues was related with invasive depth(P < 0.05), clinical staging(P < 0.01) and metastasis of lymph node(P < 0.05). The expression of paxillin, CD44v6 in primary tumor tissue and metastatic lymph node was much higher than that in non-metastatic lymph node respectively(P < 0.05). Paxillin expression was not correlated with CD44v6 expression in lymph node tissues(P > 0.05). Conclusion:Paxillin and CD44v6 are over expressed in esophageal carcinoma tissue. They play an important role in invasion and progression of esophageal carcinoma and can be used as valuable biomakers to evaluate esophageal carcinoma metastasis.

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王 雷,杜媛鲲,张 雷,平育敏,孟宪利.食管鳞癌和淋巴结组织Paxillin和CD44v6的表达与临床意义[J].南京医科大学学报(自然科学版),2007,(3):264-267

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  • 收稿日期:2006-08-11
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