Objective：To compare the measurement of knee articular cartilage volume of swine between FLASH（Fast Flow Angle Shot） and MEDIC（Multi Echo Data Imagine Combination） MRI data at 3.0T. Methods：The knees of 20 swine were examined by sagittal（sag） MRI performed with a FLASH water-excitation sequence and a MEDIC. After scanning, knee cartilage plates of swine were resected. Results：Ｏbtained with quantitative MRI were compared with that obtained by direct measurement of cartilage volume of the surgically removed tissue. In the knee joint of swine, average reproducible error for cartilage volume was 2.5 to 3.2% with sag FLASH, and 1.6 to 3.0% with sag MEDIC. Correlation coefficients between MEDIC and FLASH and morphologic analysis ranged from 0.90 to 0.98 for cartilage volume. Random pairwise differences between results obtained with FLASH and MEDIC and morphologic analysis were 4.3% to 6.8% and 2.9% to 6.6%, respectively. Systematic pairwise difference between results obtained with FLASH and MEDIC and morphologic analysis were -0.6% to 1.2% and -1.1% to 2.8%, respectively. Conclusion：Cartilage volume reproducibility was slightly higher for the MEDIC data than in the FLASH data. While sag MEDIC permits accurate analysis of cartilage morphology in all knee cartilage plates at reasonable acquisition times in the knee of swine.