核内不均一核糖核蛋白A2/B1在子宫内膜异位症组织中的表达
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Expression of heterogeneous nuclear ribonucleoprotein A2/B1 in endometriosis
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    目的:研究核内不均一核糖核蛋白A2/B1(heterogeneous nuclear ribonucleoprotein A2/B1,hnRNP A2/B1)在正常子宫内膜、子宫内膜异位症(EMs)患者在位内膜、患者异位内膜间的表达差异。方法:用免疫组织化学法和Western blot分析,研究3例增生中晚期正常子宫内膜、3例增生中晚期EMs患者的在位内膜和异位内膜中,hnRNP A2/B1蛋白的表达差异。结果:hnRNP A2/B1主要表达于间质和腺上皮细胞的细胞核内,且EMs患者在位内膜和异位内膜中的表达强度,均低于正常内膜中的表达(P < 0.05);而患者在位内膜和异位内膜中的表达,无明显差异(P > 0.05)。结论:hnRNP A2/B1可能参与EMs的发生和发展。

    Abstract:

    Objective:To study the different expression of heterogeneous nuclear ribonucleoprotein A2/B1(hnRNP A2/B1) among normal endometria, eutopic and ectopic endometria of patients with endometriosis. Methods:The expression differences among three normal proliferate-stage endometria, three proliferatestage eutopic and ectopic endometria of patients with endometriosis was examined by immunohistochemistry and Western blot. Results:hnRNP A2/B1 was located in the nucleus of both epithelial glands and stroma. The expression level of hnRNP A2/B1 in ectopic and eutopic endometria of patients with endometriosis both were weaker than that in normal endometria(P < 0.05), while the difference between ectopic and eutopic endometria in the patients was not significant(P > 0.05). Conclusion:hnRNP A2/B1 may play an important role in the pathogenesis of endometriosis.

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康苏娅,顾丽萍,谢满鑫,林 敏,马 翔,朱叶飞,沙家豪,刘嘉茵,周作民,韩素萍,冒韵东.核内不均一核糖核蛋白A2/B1在子宫内膜异位症组织中的表达[J].南京医科大学学报(自然科学版),2007,(5):449-451

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  • 收稿日期:2006-11-13
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