支气管哮喘患儿外周血白细胞介素19水平及其临床意义
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The clinical value of the Interleukin-19 level in peripheral blood of children patients with bronchial asthma
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    摘要:

    目的:检测哮喘患儿外周血白介素19(IL-19)水平,探讨其临床意义。方法:实验分3组,发作期组(21例)、缓解期组(19例)、正常对照组(22例)。采用酶联免疫吸附试验(ELISA)法检测外周血IL-19、IgE水平,血细胞分析仪计数外周血嗜酸性粒细胞(EOS)。结果:与对照组比较,发作期组和缓解期组外周血IL-19、IgE水平和EOS明显增高(P < 0.01)。发作期组IL-19和EOS水平高于缓解期组(P < 0.05),而发作期组IgE水平与缓解期组比较差异无显著性。相关性分析显示,外周血IL-19与IgE及EOS均呈正相关(r =0.837, P < 0.01;r =0.742,P < 0.01 )。结论:外周血IL-19在哮喘不同时期上升程度不同。IL-19可能在哮喘发病机制中发挥重要作用,观察其变化有助于哮喘临床诊断和病情监测。

    Abstract:

    Objective:To study the level of interleukin 19(IL-19)in peripheral blood of children with asthma and investigate its importance. Methods:Three groups were in the experiment:the acute onset group of asthma(21 patients), the catabasis group of asthma(19 patients), and health control group(22 cases ).The level of IL-19 and IgE in peripheral blood was respectively determined with ELISA. The accurate number of EOS in peripheral blood was counted with cytoanalyze. Results:Compared with the children of control group, the levels of IL-19, IgE and the quantity of EOS in peripheral blood of the patients with Asthma were obvious higher(P < 0.01).The level of IL-19 and the quantity EOS of the patients of acute attack group were higher than those of the patients of catabasis group(P < 0.05), but there is no significant difference in the level of IgE between the two groups of asthma. Furthermore, the results of correlation analysis showed that the levels of IL-19 positively correlated to the level of IgE and the quantity of EOS respectively in blood(r = 0.837, P < 0.01;r = 0.742, P < 0.01). Conclusion:The IL-19 level of the children with asthma was always higher than that of health children, and the ascending degree of the IL-19 level are different during various periods of asthma. It may be inferred that IL-19 can play an important role in the pathogenesis of asthma, and observing the change of the level of IL-19 can make for the clinical diagnosis and monitoring the pathogenetic condition of asthma.

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孔炜,汪晓莺.支气管哮喘患儿外周血白细胞介素19水平及其临床意义[J].南京医科大学学报(自然科学版),2007,(5):499-501506

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  • 收稿日期:2006-09-05
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