非糖尿病患者脂联素基因SNP+276 G/T单核苷酸多态性与冠心病的相关性研究
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南京科技局科技社会发展项目(200401068-27)


Correlation between single nucleotide polymorphism(SNP+276 G/T) of adiponectin gene and coronary artery disease in non-diabetic population
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    目的:探讨在中国南京地区汉族人群中脂联素单核苷酸多态性SNP+276 G/T 与冠心病的关系-方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP) 方法,分析了266例非糖尿病患者的冠脉造影结果和脂联素单核苷酸多态性( SNP+276 G/T)的关系,研究设立了病例组和正常对照组-结果:相对于T/T基因型,G/G基因型修正后的OR值为3.16,(P < 0.05);G/G+G/T基因型的修正后OR值为2.69,(P < 0.05)- 结论:脂联素 SNP+276 G/T 各种基因型和冠心病的发病密切相关,G/G基因型很可能是冠心病的易感基因型-

    Abstract:

    Objective:To investigate the relationship between single nucleotide polymorphisms(SNP) of adiponectin gene(SNP+ 276G/T) and coronary artery disease in non-diabetic Chinese han population. Methods:The single nucleotide polymorphisms(SNP) at positions 276 in adiponectin gene were determined by polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP) assay in persons of Han nationality in Nanjing area, including 135 patients with coronary artery disease(CAD group) and 131 normal controls(control group). Results:Adjusted OR of G/G genotype is 3.16(P < 0.05); adjusted OR of G/G+G/T is 2.69,(P < 0.05). Conclusion:The distribution of SNP+276 genotypes were significantly different between CAD group and control group. And G/G genotype appeared more frequently in patients with coronary artery disease than normal population, which suggests that adiponectin gene seems to closely associate with coronary artery disease in Chinese han population.

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陆峰,王连生,杨志健,朱铁兵,王志广,朱怀军,汤纳平,曹克将,黄峻,桂鸣.非糖尿病患者脂联素基因SNP+276 G/T单核苷酸多态性与冠心病的相关性研究[J].南京医科大学学报(自然科学版),2007,(7):736-739

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  • 收稿日期:2006-11-24
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