棉子糖低钾右旋糖酐液对猪供体肺灌注保护作用的病理学研究
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A pathologiacal study of pig lung donor perfused with raffinose-low potassium dextran sol-ution for lung transplantation
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    摘要:

    目的:探讨棉子糖低钾右旋糖酐液(raffinose-low-potassium dextran solution,R-LPD液)供肺灌注保存后对肺组织形态学变化的影响-方法:应用光镜-电镜和免疫组化技术对低钾右旋糖酐液(low-potassium dextran solution,LPD 液)和R-LPD 液灌注保存的各10 例猪供肺组织按不同的保存时间段进行对比观察-结果:随着保存时间的延长,供肺的形态结构改变也逐渐明显,保存24 h后,LPD 液灌注组肺泡间隔断裂,肺泡上皮细胞变性-坏死-脱落,肺泡壁及血管周围间质组织水肿;而R-LPD 液灌注组形态改变则相对较轻-结论:R-LPD 液与LPD 液相比,在供肺灌注保存中更能起到保护肺泡上皮细胞的作用-

    Abstract:

    Objective:To observe the change of the morphological structure in lung perfused with raffinose-low-potassium dextran solution(R-LPD-蒺S). Methods:The 20 pig donor lung perfused with low-potassium dextran solution(LPD-蒺S) and R-LPD-蒺S was observed by light microscope, electronic microscope and immunohistochemistry. Results:Morphologic changes of the structure in the tissue cell were gradually obvious along with time. After 24 h of preservation, the tissue of donor lung perfused with LPD-蒺S showed a decreased number of intact type Ⅱ pneumocytes and significant cellular necrosis. Interstitial and alveolar edema with interstitial macrophage infiltration was also observed. Alveolar capillaries were collapsed. In contrast, R-LPD’S lungs showed only mild alterations such as minor interstitial edematous expansion, fewer damaged cells, and minor capillary injury. Conclusion:R-LPD’S exerts a cytoprotective effect on preservation of donor lung during pulmonary grafts, and it should be superior to LPD-S for this purpose.

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杨国仪,陈静瑜,夏钰弘,洪建刚,虞敏红,吴 波,姜少军,周晓军.棉子糖低钾右旋糖酐液对猪供体肺灌注保护作用的病理学研究[J].南京医科大学学报(自然科学版),2007,(8):860-863

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  • 收稿日期:2006-11-05
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