牙周治疗前后龈沟液中P物质含量的变化
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Changes of substance P in gingival crevicular fluid in response to periodontal treatment
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    目的:通过观察牙周非手术治疗前后龈沟液中P物质含量的变化,了解牙周组织恢复健康的程度-方法:对15名牙周炎患者进行牙周非手术治疗,术前及术后8周用滤纸袋内取样法在测试牙位取GCF样本30 s,以放射免疫分析法测定其SP含量-结果:所有进行牙周治疗测试部位的临床条件均有明显改善,表现为P物质含量(pg /30s总量)从术前的45.48下降到术后的10.11(P < 0.05),浓度从术前的36.90 pg/ml下降到术后的25.82 pg/ml(P < 0.05)-结论:牙周炎症减轻,其程度与龈沟液中神经肽P物质的降低相关-

    Abstract:

    Objective:To investigate the effects of periodontal treatment on the levels of substance P(SP) in gingival crevicular fluid(GCF), resulting in a return to periodontal health. Method:The course of non-surgical treatment was performed in 15 patients. Clinical indexes were measured at periodontitis site before treatment and at 8 weeks after the completion of treatment in each subject. A 30-s sample of GCF was collected from each test site using perio paper strips. The volume of GCF was calculated, and the SP level was analysed by radioimmunoassay. Results:The clinical condition of all test sites improved as a result of the periodontal treatment. The levels(pg/30 s sample) of SP fell from 45.48 before treatment to 10.11 after treatment(P < 0.05). The concentration(pg/ml) of SP in GCF fell from 36.90 to 25.82(P < 0.05). Conclusion:The reduction in inflammation resulting from effective periodontal treatment was associated with a reduction of neurokinin SP in gingival crevicular fluid.

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倪 杰,孙卫斌.牙周治疗前后龈沟液中P物质含量的变化[J].南京医科大学学报(自然科学版),2007,(9):964-966

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  • 收稿日期:2007-04-19
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