两种结合雌激素对改善绝经期综合征的临床观察
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省高校自然科学研究基金资助(05KJB320087)


Clinical observation of two kinds of conjugated estrogen in the treatment of menopausal symptoms
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察比较结合雌激素片(试验组)与结合雌激素倍美力片(对照组)治疗绝经期综合征的疗效和安全性-方法:选取60例符合诊疗标准的患者随机分成试验组和对照组,每日服结合试验或对照药物1片, 28天为1周期,第15~28天均添加安宫黄体酮片每日4 mg,通过随机开放平行对照方法对两组潮热症状评分,Kupperman评分-血清 E2水平-血脂的变化及不良反应发生情况比较-结果:两组治疗后,潮热症状评分及Kupperman评分均明显下降,血清雌二醇-甘油三酯(TG)和高密度脂蛋白(HDL-C)均升高,低密度脂蛋白(LDL-C)降低,组内比较(P < 0.001),差异有统计学意义-组间等效性检验比较(P > 0.05),无显著性差异-不良反应两组之间比较(P > 0.05),无显著差异-结论:国产结合雌激素片和倍美力一样能有效-安全地治疗妇女绝经期综合征-

    Abstract:

    Objective:To compare the efficacy and the safety of conjugated estrogen(CE) in the treatment of menopausal with conjugated equine estrogen(Premarin). Methods:According to the standards ,a total of 60 patients were randomly divided into 2 groups:CE group and Premarin group,a period of 28 days,and from 15 to 28 days plus medroxyprogesterone(MPA) 4 mg Daily.Treatment lasted for 3 periods. This randomly publicly parallel was adopted to compare the hot flashes symptom scores,serum level of estradiol,Kupperman measurement Index and serum lipid. Results:The scores of menopausal symptom,hot flash scores and the serum level of estradiol ascent. TG-HDL-C ascented and LDL-C were reduced after treatment with CE or Premarin(P < 0.001),No significant differences were discovered between the two groups through equivalence margin(P > 0.05). There are no significant differences between the two groups on side effect(P > 0.05). Conclusion:CE is safe and effective in treatment of menopausal symptoms.

    参考文献
    相似文献
    引证文献
引用本文

王美莲,钟华绣,孙丽洲,王淑玉.两种结合雌激素对改善绝经期综合征的临床观察[J].南京医科大学学报(自然科学版),2007,(9):989-

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2007-04-09
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期:
通知关闭
郑重声明