乌司他丁对体外循环心内直视术患者具脑保护的作用
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Clinical study of ulinastatin on brain protection during cardiopulmonary bypass
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    目的:探讨围麻醉期乌司他丁对体外循环(CPB)下行心脏手术患者全身及脑部炎性反应的影响及其脑保护作用-方法:择期心脏瓣膜置换患者24例,随机分为乌司他丁组(U组)和对照组(C组)-U组患者在麻醉后和转机时分别静脉泵注乌司他丁,泵注时间均为1 h-C组患者则给予等量容积的生理盐水代替-分别于麻醉后手术前(T1)-体外循环开始后30 min(T2)-体外循环结束后1 h(T3)-4 h(T4)和20 h(T5)同时抽取动脉血和颈静脉球血-采用ELISA法测定动静脉血浆中TNF-α-IL-6及颈静脉球血S100B蛋白的浓度,并计算同一时点颈静脉球血和动脉血之差△TNF-α-△IL-6值-结果:与各自T1相比,两组患者血浆TNF-α-IL-6-△TNF-α-△IL-6的浓度在T2-T3-T4-T5明显升高(P < 0.01或P < 0.05)且C组升高的幅度明显大于U组(P < 0.01或P < 0.05)-与T1相比,两组患者血浆S100B蛋白水平在体外循环开始后明显升高(P < 0.01),T3达到高峰,T4 开始下降,T5明显下降-U组T2-T3-T4-T5的S100B蛋白浓度升高的水平明显低于C组(P < 0.01)-结论:乌司他丁可减轻CPB心脏手术患者全身和脑局部炎性反应,可降低颈静脉球血浆中S100B蛋白水平升高的幅度,具有一定的脑保护作用-

    Abstract:

    Objective:To investigate the effects of ulinastatin(UTI) on systemic and cerebral inflammatory response and on brain protection during cardiopulmonary bypass(CPB). Methods:Twenty-four patients,undergoing elective cardiac valve replacement were randomly divided into 2 groups:ulinastatin group(Group U,n = 12) and control group(Group C,n = 12). In group U,UTI(1×104 U/kg) was infused intravenously after the induction of anesthesia and during CPB, respectively. Each infusion time was about 1 h. In Group C,normal saline was given instead of UTI. Blood samples were taken simultaneously from artery and jugular bulb after induction of anesthesia(T1),0.5 h after CPB beginning(T2),1 h(T3),4 h(T4) and 20 h(T5) after CPB termination for determination of TNFα,IL-6 and S100B. S100B samples were taken only from jugular bulb. The jugular bulb-arterial gradients of these cytokines(△TNFα and △IL-6) were calculated. Results:The concentration of TNF-α,IL-6,△TNF-αand △IL-6 elevated dramatically at T2,T3,T4,T5 in both groups(P < 0.01 or P < 0.05). TNF-α,IL-6,△TNF-α and △IL-6 at T2,T3,T4,T5 in group C were higher than that at the corresponding time point in group U. Compared with T1 point,the level of S100B increased markedly 30 min after CPB(T2)(P < 0.01),reached peak level at T3 point and began to decrease at T4 point in both groups. The levels of S100B at T2,T3,T4,T5 in Group U were lower compared with group C at the corresponding time point. Conclusion:Systemic and cerebral inflammatory response during CPB could be alleviated by ulinastatin, and Jugular bulb blood levels of S100B Protein decreased by ulinastatin. Ulinastatin had protective effect on the brain injury during CPB.

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邵东华,杭黎华,傅诚章,王 洪,杨映红.乌司他丁对体外循环心内直视术患者具脑保护的作用[J].南京医科大学学报(自然科学版),2007,(12):1407-1410

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  • 收稿日期:2007-04-16
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