Objective:To review the experience of using synchronized intermittent mandatory ventilation(SIMV) in the treatment of neonatal acute lung injury. Methods:Sixty-two neonates suffering from acute respiratory distress syndrome and requiring mechanical ventilation were devided into two groups,32 by SIMV and 30 by intermittent positive pressure ventilation(IPPV). FiO2,PIP,oxygenation index,average time of ventilation and complications were compared between the two groups. Results:FiO2 and PIP dropped in 6 hours of ventilation in SIMV group. Oxygenation index was obviously improved 2 h after use of SIMV and 6 h after use of IPPV. Average time of ventilation was shorter in SIMV group than in IPPV group. The rate of complications was less in SIMV group than in IPPV group. Conclusion:SIMV was superior to IPPV in the treatment of neonatal acute lung injury.