多发性骨髓瘤患者血清血管内皮生长因子?IL-6水平的观察
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Quantative measurement of VEGF and IL-6 in the serum of patients with multiple myeloma
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    目的:研究多发性骨髓瘤(MM)患者血清中血管内皮生长因子(VEGF)及IL-6的含量与其临床分期及预后的关系-方法:采用酶联免疫吸附测试(ELISA)法,分别检测30例多发性骨髓瘤患者血清中VEGF及IL-6含量,并观察其与MM的临床分期-肿瘤量分级的关系,及对病情预后判断的预测意义-结果: MM患者血清中的VEGF及IL-6含量较正常对照组均明显升高(P < 0.001)-Ⅰ期-Ⅱ期MM患者的血清VEGF水平明显低于Ⅲ期患者(P < 0.001),Ⅰ期与Ⅱ期患者间血清VEGF含量亦呈显著性差异(P < 0.001);随着临床分期增加,MM患者血清IL-6水平呈递增趋势,各期间比较均有显著性差异(P < 0.01)-IL-6及VEGF水平在临床参数Hb-β2-MG异常组高于其正常组(P < 0.05),提示与瘤细胞负荷相关-结论:血管生成的调控因子VEGF和骨髓基质细胞分泌的IL-6可能与MM的疾病进程有关,其水平升高是MM的预后不良因素-

    Abstract:

    Objective:To explore the changes and clinical significances of vascular endothelial growth factor and interleukin-6 serum level in multiple myeloma(MM). Methods:The serum levels of VEGF and IL-6 were detected by enzyme-linked immunosorbent assays in 30 patients with MM. The relationship between the increased serum levels of these two cytokines and MM clinical stage as well as therapic effect was studied. Results:The MM patients had significantly higher VEGF and IL-6 serum levels than the control(P < 0.001). Serum level of VEGF and IL-6 were elevated and correlated with clinical stages. VEGF were highest(mean 327.65 pg/ml) in stage Ⅲ,and there was significant difference(P < 0.001) of the VEGF serum levels between stageⅠand stageⅡ. IL-6 levels increased progressively according to clinic stages and it had significant difference among stages respectively(P < 0.01). The IL-6 and VEGF serum levels were higher in patients with the abnormal Hb and beta2-MG(P < 0.05). No correlation was found between the serum VEGF level and percentage of bone marrow plasma cells and monoclonal Ig levels. Conclusion:An elevated serum level of VEGF and IL-6 was associated with a poor prognosis. The two cytokines might be useful in monitoring the disease progression and triggering the targeted MM therapies.

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周 民,肖 溶,岑 岭,陈 涛,杨建和,姜乃可,章 艳,王锡清.多发性骨髓瘤患者血清血管内皮生长因子?IL-6水平的观察[J].南京医科大学学报(自然科学版),2007,(12):1433-1435

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  • 收稿日期:2007-05-16
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