改良viscocanalostomy术中新型植入物的实验研究
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Experimental studies of Reforming viscocanalostomy with new implantation materials imp-lanted in rabbit eyes
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    摘要:

    目的:探索新型植入物可吸收牛心包补片-不可吸收牛心包补片在改良viscocanalostomy(VCO)中应用的安全性及有效性;方法:将18只新西兰白兔随机分为A-B两个实验组和C对照组,每组6只-在A-B组白兔改良VCO的巩膜腔隙中分别植入不可吸收牛心包补片-可吸收牛心包补片,C组不植入任何植入物-观察术后不同时间巩膜腔隙存留情况及周围组织反应情况-结果:A-B组术后滤过泡形成及存留时间均优于对照组-手术区域周围组织反应轻微,可吸收牛心包补片组反应更为轻微-巩膜滤过空腔的保持与植入物有关,术后12周时A-B组眼巩膜腔隙仍维持较好,C组眼手术区域瘢痕形成明显-结论:植入物有助于改良VCO术后引流道的抗瘢痕化;两种植入物都是安全的,可吸收牛心包组反应更为轻微,远期抗瘢痕化效果可能更好-

    Abstract:

    Objective:To evaluate the effect of inhibiting scar formation and safety of reforming viscocanalostomy with absorbable and non-absorbable pericardial patch implantation. Methods:18 New Zealand white rabbits were equally divided into three groups as experimental groups A,B and control group C. One piece of non-absorbable pericardial patch was implanted into each eye of group A while absorbable one into each eye of group B.Nothing was implanted in group C during reforming viscocanalostomy. Internal structures and lasting time of the scleral space are observed. Results:The formed filter blebs lasted longer in group A and B than group C. The pathology process showed that the spaces in sclera of group A and B were remained while scar formation was found in control group at the twelfth week. Conclusion:Implantation of absorbable and non-absorbable pericardial patches in reforming viscocanalostomy is safe and effective that can inhibit scar formation. Reaction caused by absorbable pericardial patches is lighter than that of non-absorbable ones. Absorbable pericardial patches may lead to better result in inhibiting scar formation.

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张为中,袁志兰,于 焱,杨 勤,陈 琴,洪 瑾,帅 捷.改良viscocanalostomy术中新型植入物的实验研究[J].南京医科大学学报(自然科学版),2007,(12):1444-1446

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  • 收稿日期:2007-06-17
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